Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

SiRNA delivery with exosome nanoparticles | Nature Biotechnology Skip to main content Thank
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Amyloid β1–42, a major component of amyloid plaques, binds with exceptionally high affinity
to the α7 nicotinic acetylcholine receptor and accumulates intracellularly in neurons of …

Resting-state networks dissociate in the early stage of Alzheimer's disease (AD). The
posterior cingulate cortex (PCC) in AD brain is vulnerable to isolation from the rest of brain …

Agonists and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
(nAChR) are currently being developed for the treatment of cognitive disturbances in …

The association between nicotinic acetylcholine receptor (nAChR) dysfunction and cognitive
decline in Alzheimer's disease (AD) has been widely exploited for its therapeutic potential …

The PACSINs are a family of cytoplasmic phosphoproteins that play a role in vesicle
formation and transport. We report the cloning and cDNA sequencing of PACSIN 3 and the …

Alzheimer's disease (AD) is characterized neuropathologically by the deposition of different
forms of amyloid β-protein (Aβ) including variable amounts of soluble species that correlate …

Although there is still no known effective preventative treatment or cure for Alzheimer's
disease (AD), the development of new drugs that target pathological features that appear …