Sleep-induced apnea and disordered breathing refers to intermittent, cyclical cessations or
reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence …

Increasing the lifespan of a population is often a marker of a country's success. With the
percentage of the population over 65 yr of age expanding, managing the health and …

Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …

Cerebral blood flow (CBF) and its distribution are highly sensitive to changes in the partial
pressure of arterial CO2 (PaCO2). This physiological response, termed cerebrovascular …

The response of cerebral vasculature to exercise is different from other peripheral
vasculature; it has a small vascular bed and is strongly regulated by cerebral autoregulation …

The ventral surface of the rostral medulla oblongata has been suspected since the 1960s to
harbor central respiratory chemoreceptors [ie, acid-activated neurons that regulate breathing …

Central chemoreception traditionally refers to a change in ventilation attributable to changes
in CO 2/H+ detected within the brain. Interest in central chemoreception has grown …

Neurophysiologically, central apnea is due to a temporary failure in the pontomedullary
pacemaker generating breathing rhythm. As a polysomnographic finding, central apneas …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

By definition central respiratory chemoreceptors (CRCs) are cells that are sensitive to
changes in brain PCO2 or pH and contribute to the stimulation of breathing elicited by …