Lyme disease is the most common vector-borne infectious disease in the United States, in
part because a vaccine against it is not currently available for humans. We propose utilizing …

Background Lyme borreliosis, potentially associated with serious long-term complications, is
caused by the species complex Borrelia burgdorferi sensu lato. We investigated a novel …

The deer tick transmits nearly half of the known tick-borne pathogens in the United States,
and its expanding geographic range increases the risk of human infection. To decrease the …

ABSTRACT Introduction Transmitted by ticks, Lyme disease is the most common vector-
borne disease in the Northern hemisphere. Despite the geographical expansion of human …

Introduction The incidence of Lyme disease (LD) in Canada and the United States has risen
over the last decade, nearing 480,000 cases each year. Borrelia burgdorferi sensu lato, the …

The Lyme disease (LD) vaccine formerly approved for use in the United States consisted of
recombinant outer surface protein A (OspA) from Borrelia burgdorferi sensu stricto (ss), the …

44 is a human monoclonal antibody capable of passively protecting mice against tick‐
mediated infection with Borreliella burgdorferi, the bacterial genospecies responsible for …

Camelid-derived, single-domain antibodies (VHHs) have proven to be extremely powerful
tools in defining the antigenic landscape of immunologically heterogeneous surface …

Lyme disease vaccines based on recombinant O uter s urface p rotein A (OspA) elicit
protective antibodies that interfere with tick-to-host transmission of the disease-causing …

Lyme disease is a tick-borne zoonosis caused by certain genospecies of the spirochete
Borrelia burgdorferi sensu lato. 1 The organism cycles naturally among small mammal and …