Interfacing nanomaterials with biology through ligand engineering

A Gupta, W Ndugire, CM Hirschbiegel… - Accounts of Chemical …, 2023 - ACS Publications
Conspectus Nanoparticles (NPs) have incredible potential in biology and biomedicine. Gold
nanoparticles (AuNPs) have become a cornerstone of the nanomedicine revolution due to …

Nanozyme-activating prodrug therapies: A review

Y Wu, W Chen, C Wang, D Xing - Chinese Chemical Letters, 2023 - Elsevier
Enzyme prodrug therapies (EPTs) have been intensively explored as attractive approaches
to selective activation of systemically administered benign prodrugs by the exogenous …

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Q Fu, C Wei, M Wang - ACS nano, 2024 - ACS Publications
Cancer, as one of the leading causes of death worldwide, drives the advancement of cutting-
edge technologies for cancer treatment. Transition-metal-based nanozymes emerge as …

[HTML][HTML] Biomimetic and bioorthogonal nanozymes for biomedical applications

C Keum, CM Hirschbiegel, S Chakraborty, S Jin… - Nano …, 2023 - Springer
Nanozymes mimic the function of enzymes, which drive essential intracellular chemical
reactions that govern biological processes. They efficiently generate or degrade specific …

Dumbbell-shaped bimetallic AuPd nanoenzymes for NIR-II cascade catalysis-photothermal synergistic therapy

Z Tang, Y Hou, S Huang, NS Hosmane, M Cui, X Li… - Acta Biomaterialia, 2024 - Elsevier
The noble metal NPs that are currently applied to photothermal therapy (PTT) have their
photoexcitation location mainly in the NIR-I range, and the low tissue penetration limits their …

Engineered Zwitterionic Diblock Copolymer‐siRNA Polyplexes Provide Highly Effective Treatment of Triple‐Negative Breast Cancer in a 4T1 Murine Model

T Jeon, R Goswami, H Nagaraj… - Advanced Functional …, 2024 - Wiley Online Library
Self‐assembly of small interfering RNA (siRNA) with a block copolymer featuring
guanidinium and zwitterion functionalized blocks generates core‐shell‐like nanovectors that …

Quantitative imaging of the sub-organ distributions of nanomaterials in biological tissues via laser ablation inductively coupled plasma mass spectrometry

T Jantarat, JD Lauterbach, J Doungchawee… - Analyst, 2023 - pubs.rsc.org
Nanomaterials have been employed in many biomedical applications, and their distributions
in biological systems can provide an understanding of their behavior in vivo. Laser ablation …

[HTML][HTML] Catalytic imaging-guided cancer therapy using non-coordinated and coordinated nanozymes

M Falahati, M Sharifi, Y Vahdani, S Haghighat… - Coordination Chemistry …, 2024 - Elsevier
Nanozymes with and without coordinated structures, in addition to performing enzyme-mimic
activities through converting O2 radical dot–to H 2 O 2 or H 2 O 2 into O 2 and radical dot …

Nanozyme-based cancer theranostics: A scientometric analysis and comprehensive review

Y Xing, F Yasinjan, S Sun, J Yang, Y Du, H Zhang… - Nano Today, 2024 - Elsevier
Nanozymes, possessing enzyme-like characteristics, have emerged as valuable
nanomaterials in biomedical applications owing to their advantages over natural enzymes …

[HTML][HTML] Polarization of macrophages to an anti-cancer phenotype through in situ uncaging of a TLR 7/8 agonist using bioorthogonal nanozymes

X Zhang, Y Liu, M Jiang, JA Mas-Rosario, S Fedeli… - Chemical …, 2024 - pubs.rsc.org
Macrophages are plastic cells of the immune system that can be broadly classified as having
pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotypes. M2-like macrophages …