The Notch signaling pathway is an architecturally simple signaling mechanism, well known
for its role in cell fate regulation during organ development and in tissue homeostasis. In …

Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal
surface of microvessels, where they provide structural and biochemical support. Pericytes …

The heart depends on a functional vasculature for oxygenation and transport of nutrients,
and it is of interest to learn how primary impairment of the vasculature can indirectly affect …

In China, the sale of freshly slaughtered chickens is becoming increasingly popular in
comparison with that of live chickens, and due to this emerging trend, the skin and feather …

Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel …

Notch signaling controls multiple aspects of embryonic development and adult homeostasis.
Alagille syndrome is usually caused by a single mutation in the jagged canonical Notch …

In this perspective, we discussed emerging data indicating a role for Notch signalling in
inherited disorders of the heart failure with focus on hypertrophic cardiomyopathy (HCM) …

Transcription factors (TFs) play a crucial role in regulating the dynamic and precise patterns
of gene expression required for the initial specification of endothelial cells (ECs), and during …

A wide range of life-threatening conditions with complicated pathogenesis involves
neurovascular disorders encompassing Neurovascular unit (NVU) damage. The …

Purpose Vascular endothelium plays a central role in the pathogenesis of acute and chronic
radiation injuries, yet the mechanisms which promote sustained endothelial dysfunction and …