DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage
exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes …

ABSTRACT ADP-ribose is a versatile modification that plays a critical role in diverse cellular
processes. The addition of this modification is catalyzed by ADP-ribosyltransferases, among …

Endoplasmic reticulum (ER) stress, prompted by the accumulation of misfolded or unfolded
proteins, triggers the activation of the unfolded protein response (UPR) pathway to restore …

Inhalation exposures to dihydroxyacetone (DHA) occur through spray tanning and e-
cigarette aerosols. Several studies in skin models have demonstrated that millimolar doses …

The ATP-dependent molecular chaperone Cdc48 (in yeast) and its human counterpart p97
(also known as VCP), are essential for a variety of cellular processes, including the removal …

Duplication of the genome requires the replication apparatus to overcome a variety of
impediments, including covalent DNA adducts, the most challenging of which is on the …

DNA-protein crosslinks (DPCs) are among the most ubiquitous and heterogenous lesions
that arise from the covalent linking of a protein with a nucleotide residue on DNA (Stingele et …

DNA–protein crosslinks (DPCs) represent a unique and complex form of DNA damage
formed by covalent attachment of proteins to DNA. DPCs are formed through a variety of …

Inflammation is an early immune response against invading pathogens and damaged
tissue. Although beneficial, uncontrolled inflammation leads to various diseases and may be …

Colorectal cancer (CRC) currently represents one of the most commonly diagnosed tumors,
accounting for 10% of all cancer diagnoses and cancer-related deaths. The first-line …