Squish and squeeze—the nucleus as a physical barrier during migration in confined environments
From embryonic development to cancer metastasis, cell migration plays a central role in
health and disease. It is increasingly becoming apparent that cells migrating in three …
health and disease. It is increasingly becoming apparent that cells migrating in three …
The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue
J Swift, DE Discher - Journal of cell science, 2014 - journals.biologists.com
How cells respond to physical cues in order to meet and withstand the physical demands of
their immediate surroundings has been of great interest for many years, with current …
their immediate surroundings has been of great interest for many years, with current …
Nuclear deformability constitutes a rate-limiting step during cell migration in 3-D environments
PM Davidson, C Denais, MC Bakshi… - Cellular and molecular …, 2014 - Springer
Cell motility plays a critical role in many physiological and pathological settings, ranging
from wound healing to cancer metastasis. While cell migration on 2-dimensional (2-D) …
from wound healing to cancer metastasis. While cell migration on 2-dimensional (2-D) …
Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer
Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to …
However, it remains unclear whether the disturbed nuclear structure directly contributes to …
The wide and growing range of lamin B-related diseases: from laminopathies to cancer
C Evangelisti, I Rusciano, S Mongiorgi… - Cellular and Molecular …, 2022 - Springer
B-type lamins are fundamental components of the nuclear lamina, a complex structure that
acts as a scaffold for organization and function of the nucleus. Lamin B1 and B2, the most …
acts as a scaffold for organization and function of the nucleus. Lamin B1 and B2, the most …
Biomarkers in cancer detection, diagnosis, and prognosis
Biomarkers are vital in healthcare as they provide valuable insights into disease diagnosis,
prognosis, treatment response, and personalized medicine. They serve as objective …
prognosis, treatment response, and personalized medicine. They serve as objective …
Lamin A/C: function in normal and tumor cells
N Dubik, S Mai - Cancers, 2020 - mdpi.com
Simple Summary The aim of this review is to summarize lamin A/C's currently known
functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many …
functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many …
Nuclear mechanics in cancer
C Denais, J Lammerding - Cancer biology and the nuclear envelope …, 2014 - Springer
Despite decades of research, cancer metastasis remains an incompletely understood
process that is as complex as it is devastating. In recent years, there has been an increasing …
process that is as complex as it is devastating. In recent years, there has been an increasing …
Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN 1, SUN 2, and nesprin‐2 in breast cancer
A Matsumoto, M Hieda, Y Yokoyama… - Cancer …, 2015 - Wiley Online Library
Cancer cells exhibit a variety of features indicative of atypical nuclei. However, the molecular
mechanisms underlying these phenomena remain to be elucidated. The linker of …
mechanisms underlying these phenomena remain to be elucidated. The linker of …
Nuclear lamins in cancer
Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying
in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies …
in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies …