Over the past decade, RAS oncogenic proteins have transitioned from being deemed
undruggable to having two clinically approved drugs, with several more in advanced stages …

Within the tumor microenvironment (TME), regulatory T cells (Tregs) play a key role in
suppressing anticancer immune responses; therefore, various strategies targeting Tregs are …

Using meta-analyses, we introduce a unicellular attractor (UCA) model integrating essential
features of the 'atavistic reversal','cancer attractor','somatic mutation','genome chaos', and …

The CXC chemokine receptor 4 (CXCR4, CD184) is a member of the G protein-coupled
receptor family that is expressed in most leukocytes. Overexpression of CXCR4 is …

Immunotherapies have revolutionized the landscape of cancer treatment. Regulatory T cells
(Tregs), as crucial components of the tumor immune environment, has great therapeutic …

Intrinsic immunosuppressive tumor microenvironment (ITM) and insufficient tumor infiltration
of T cells severely impede the progress of glioblastoma (GBM) immunotherapy. In this study …

Single-cell sequencing is a technique for detecting and analyzing genomes, transcriptomes,
and epigenomes at the single-cell level, which can detect cellular heterogeneity lost in …

Background: Gastric cancer (GC) is a malignant tumor with high prevalence and fatality.
Cuproptosis is a recently identified copper-dependent programmed cell death mechanism …

Breast cancer (BC), one of the most widespread and devastating diseases affecting women
worldwide, presents a significant public health challenge. This review explores the emerging …

Simple Summary Tumors escape from the host immune control by upregulation of inhibitory
immune checkpoints. Immune checkpoint inhibition (ICI) has become the standard of care …