Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies. It is
characterized by a complex and immunosuppressive tumor microenvironment (TME), which …

Background & aims The effectiveness of adjuvant immunotherapy to diminish recurrence
and improve long-term prognosis following curative-intent surgical resection for …

Background Immune‐checkpoint blockade (ICB) therapy shows promise for treating
aggressive triple‐negative breast cancer (TNBC). However, only some patients benefit from …

Background: Gastric cancer (GC) is a malignant tumor with high prevalence and fatality.
Cuproptosis is a recently identified copper-dependent programmed cell death mechanism …

Background During tumor growth, tumor cells interact with their tumor microenvironment
(TME) resulting in the development of heterogeneous tumors that promote tumor occurrence …

The anti-cancer effect of selenite (SeO 3 2−) is limited by its short half-life and narrow
therapeutic window. Peroxynitrite (ONOO−), the most active reactive nitrogen species (RNS) …

Th1-like Treg cells are dressed to suppress anti-tumor immunity: Immunity Skip to Main Content
Advertisement Immunity This journal offers authors two options (open access or subscription) to …

Tumor cells can evade immune surveillance by expressing immune checkpoint molecule
ligands, resulting in effective immune cell inactivation. Immune checkpoint blockades (ICBs) …

Lactate plays an important role in shaping immune tolerance in tumor microenvironment
(TME) and correlates with poor prognosis in various solid tumors. Overcoming the immune …

Immunosuppression by the tumor microenvironment is a pivotal factor contributing to tumor
progression and immunotherapy resistance. Priming the tumor immune microenvironment …