Bromodomain-containing protein 4 (BRD4) is an intracellular protein that regulates
expression of various cellular functions. This study investigated whether BRD4 inhibition can …

Head and neck squamous cell carcinoma (HNSCC) is a formidable cancer type that poses
significant treatment challenges, including radiotherapy (RT) resistance. The metabolic …

In the genesis and progression of cardiovascular diseases involving both innate and
adaptive immune responses, inflammation plays a pivotal and dual role. Studies in …

Translational research plays a key role in drug development and biomarker discovery for
hepatocellular carcinoma (HCC). However, unique challenges exist in this field because of …

Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing
durable remissions in responding patients. However, they are associated with variable …

Immune Checkpoint Inhibitors (ICIs) therapy has advanced significantly in treating malignant
tumors, though most 'cold'tumors show no response. This resistance mainly arises from the …

Background Pancreatic adenocarcinoma (PDAC) is a devastating disease with an urgent
need for therapeutic innovation. Immune checkpoint inhibition has shown promise in a …

With the high incidence of urogenital tumors worldwide, urinary system tumors are among
the top 10 most common tumors in men, with prostate cancer ranking first and bladder …

Drawing inspiration from recent advances in microwave ablation (MWA) induced in situ
tumor vaccination, a colloidal hydrogel comprising amphoteric gelatin nanoparticles and …

Radiotherapy is one important treatment for malignant tumours. It is widely believed today
that radiotherapy has not only been used as a local tumour treatment method, but also can …