T cells in testicular germ cell tumors: new evidence of fundamental contributions by rare subsets
Background Immune cell infiltration is heterogeneous but common in testicular germ cell
tumors (TGCT) and pre-invasive germ cell neoplasia in situ (GCNIS). Tumor-infiltrating T …
tumors (TGCT) and pre-invasive germ cell neoplasia in situ (GCNIS). Tumor-infiltrating T …
[HTML][HTML] Immunostimulatory CKb11 gene combined with immune checkpoint PD-1/PD-L1 blockade activates immune response and simultaneously overcomes the …
W Nie, Y He, X Mi, S He, J Chen, Y Zhang, B Wang… - Bioactive Materials, 2024 - Elsevier
Immunosuppression tumor microenvironment (TME) seriously impedes anti-tumor immune
response, resulting in poor immunotherapy effect of cancer. This study develops a folate …
response, resulting in poor immunotherapy effect of cancer. This study develops a folate …
Anti-stromal nanotherapeutics for hepatocellular carcinoma
Hepatocellular carcinoma (HCC), the most commonly diagnosed primary liver cancer, has
become a leading cause of cancer-related death worldwide. Accumulating evidence …
become a leading cause of cancer-related death worldwide. Accumulating evidence …
Predicting the prognosis, immune response, and immunotherapy in head and neck squamous cell carcinoma using a novel risk model based on anoikis-related …
H Deng, Z Wei, J Du, Z Shen, C Zhou - European Journal of Medical …, 2023 - Springer
Background Head and neck squamous cell carcinoma (HNSCC) is an extremely
heterogeneous and metastatic disease. Anoikis, which is a specific type of programmed …
heterogeneous and metastatic disease. Anoikis, which is a specific type of programmed …
A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment
CH Wei, L Huang, B Kreh, X Liu… - Scientific Reports, 2023 - nature.com
All-trans-retinoic acid (ATRA), the retinoic acid receptors (RARs) agonist, regulates cell
growth, differentiation, immunity, and survival. We report that ATRA-treatment repressed …
growth, differentiation, immunity, and survival. We report that ATRA-treatment repressed …
[HTML][HTML] MMP11 as a prognostic biomarker correlated with immune infiltrates in pancreatic adenocarcinoma
Z Fang, X Xu, L Tao, LS Lino-Silva… - Journal of Gastrointestinal …, 2024 - ncbi.nlm.nih.gov
Background Matrix metalloproteinase 11 (MMP11) plays a vital role in cell proliferation,
apoptosis, tumor angiogenesis, migration, and other basic processes. Currently, few studies …
apoptosis, tumor angiogenesis, migration, and other basic processes. Currently, few studies …
Carbon Ion Irradiation Activates Anti-Cancer Immunity
M Sudo, H Tsutsui, J Fujimoto - International Journal of Molecular …, 2024 - mdpi.com
Carbon ion beams have the unique property of higher linear energy transfer, which causes
clustered damage of DNA, impacting the cell repair system. This sometimes triggers …
clustered damage of DNA, impacting the cell repair system. This sometimes triggers …
A role of gut microbiota metabolites in HLA-E and NKG2 blockage immunotherapy against tumors: new insights for clinical application
W Cheng, N Zhu, J Wang, R Yang - Frontiers in Immunology, 2024 - frontiersin.org
One of major breakthroughs in immunotherapy against tumor is from blocking immune
checkpoint molecules on tumor and reactive T cells. The development of CTLA-4 and PD-1 …
checkpoint molecules on tumor and reactive T cells. The development of CTLA-4 and PD-1 …
The recruitment of CD8+ T cells through YBX1 stabilization abrogates tumor intrinsic oncogenic role of MIR155HG in lung adenocarcinoma
R Li, Y Zhang, A Wang, Y Feng, T Zhang, H Wang… - Cell Death …, 2024 - nature.com
Previous studies revealed that MIR155HG possessed an oncogenic role in many types of
tumors including lung adenocarcinoma (LUAD), along with higher expression in tumors …
tumors including lung adenocarcinoma (LUAD), along with higher expression in tumors …
SHISA3 Reprograms Tumor‐Associated Macrophages Toward an Antitumoral Phenotype and Enhances Cancer Immunotherapy
S Zhang, B Yu, C Sheng, C Yao, Y Liu… - Advanced …, 2024 - Wiley Online Library
The main challenge for immune checkpoint blockade (ICB) therapy lies in
immunosuppressive tumor microenvironment (TME). Repolarizing M2‐like tumor …
immunosuppressive tumor microenvironment (TME). Repolarizing M2‐like tumor …