Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …

In recent years, heparanase has attracted considerable attention as a promising target for
innovative pharmacological applications. Heparanase is a multifaceted protein endowed …

Heparan sulfate proteoglycans (HSPGs) are primary components at the interface between
virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage …

Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …

The incidence of diabetes is increasing globally, with cardiovascular disease accounting for
a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease …

Heparanase is the only enzyme in mammals capable of cleaving heparan sulfate, an activity
implicated in tumor inflammation, angiogenesis, and metastasis. Heparanase is secreted as …

The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the
vascular lumen. It is enriched in proteoglycans, which are proteins attached to the …

Heparanase activity is strongly implicated in structural remodeling of the extracellular matrix,
a process which can lead to invasion by tumor cells. In addition, heparanase augments …

Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, angiogenesis and metastasis. Heparanase …

• Heparan sulphate proteoglycans‐Heparan sulphate‐Heparan sulphate interactions‐Core
proteins• Heparanase‐Molecular properties of human heparanase‐1‐Working mechanism …