Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Pulmonary fibrosis is an irreversible and progressive disease affecting the lungs, and the
etiology remains poorly understood. This disease can be lethal and currently has no specific …

Perturbation of lung homeostasis is frequently associated with progressive and fatal
respiratory diseases, such as pulmonary fibrosis. Leucine-rich repeat kinase 2 (LRRK2) is …

The treatment of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF),
remains challenging as current available antifibrotic agents are not effective in halting …

Mϕs are the main innate immune cells in the lung at homeostasis, with important roles in
host defence and immune modulation. Alveolar Mϕs (AMs) and interstitial Mϕs (IMs) are the …

Liver fibrosis is a life-threatening disease, with challenging morbidity and mortality for
healthcare systems worldwide. It imparts an enormous economic burden to societies …

Fibrosis is characterized by fibroblast activation, extracellular matrix (ECM) accumulation
and infiltration of inflammatory cells that sometimes leads to irreversible organ dysfunction …

Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease of unknown etiology
with a poor prognosis. It is a chronic and progressive disease that has a distinct radiological …

ANCA-associated vasculitis (AAV) comprises granulomatosis with polyangiitis (GPA),
microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) …