Targeting fibrosis: Mechanisms and clinical trials
M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …
dysregulated wound and connective tissue repair response. Multiple organs can develop …
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
F Wu, J Yang, J Liu, Y Wang, J Mu, Q Zeng… - … and Targeted Therapy, 2021 - nature.com
To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …
The emerging roles of interstitial macrophages in pulmonary fibrosis: a perspective from scRNA-seq analyses
Y Gu, T Lawrence, R Mohamed, Y Liang… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is an irreversible and progressive disease affecting the lungs, and the
etiology remains poorly understood. This disease can be lethal and currently has no specific …
etiology remains poorly understood. This disease can be lethal and currently has no specific …
LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis
Y Tian, J Lv, Z Su, T Wu, X Li, X Hu… - Proceedings of the …, 2021 - National Acad Sciences
Perturbation of lung homeostasis is frequently associated with progressive and fatal
respiratory diseases, such as pulmonary fibrosis. Leucine-rich repeat kinase 2 (LRRK2) is …
respiratory diseases, such as pulmonary fibrosis. Leucine-rich repeat kinase 2 (LRRK2) is …
Therapeutic strategies to target connective tissue growth factor in fibrotic lung diseases
T Isshiki, S Naiel, M Vierhout, K Otsubo, P Ali… - Pharmacology & …, 2023 - Elsevier
The treatment of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF),
remains challenging as current available antifibrotic agents are not effective in halting …
remains challenging as current available antifibrotic agents are not effective in halting …
Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis
T Shi, L Denney, H An, LP Ho… - Journal of leukocyte …, 2021 - academic.oup.com
Mϕs are the main innate immune cells in the lung at homeostasis, with important roles in
host defence and immune modulation. Alveolar Mϕs (AMs) and interstitial Mϕs (IMs) are the …
host defence and immune modulation. Alveolar Mϕs (AMs) and interstitial Mϕs (IMs) are the …
[HTML][HTML] Targeting the Wnt signaling pathway in liver fibrosis for drug options: an update
Liver fibrosis is a life-threatening disease, with challenging morbidity and mortality for
healthcare systems worldwide. It imparts an enormous economic burden to societies …
healthcare systems worldwide. It imparts an enormous economic burden to societies …
Extracellular S100A4 as a key player in fibrotic diseases
Z Li, Y Li, S Liu, Z Qin - Journal of Cellular and Molecular …, 2020 - Wiley Online Library
Fibrosis is characterized by fibroblast activation, extracellular matrix (ECM) accumulation
and infiltration of inflammatory cells that sometimes leads to irreversible organ dysfunction …
and infiltration of inflammatory cells that sometimes leads to irreversible organ dysfunction …
Macrophage implication in IPF: updates on immune, epigenetic, and metabolic pathways
Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease of unknown etiology
with a poor prognosis. It is a chronic and progressive disease that has a distinct radiological …
with a poor prognosis. It is a chronic and progressive disease that has a distinct radiological …
Granulomatous inflammation in ANCA-associated vasculitis
A Müller, B Krause, A Kerstein-Stähle… - International journal of …, 2021 - mdpi.com
ANCA-associated vasculitis (AAV) comprises granulomatosis with polyangiitis (GPA),
microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) …
microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) …