Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview
Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …
decade ago, interest in their potential applications has increased exponentially. This has …
[HTML][HTML] iPSC-derived natural killer cell therapies-expansion and targeting
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …
development, especially use against hematologic malignancies. Clinical trials of NK cell …
[PDF][PDF] Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease
Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction …
immature, but this is improved by incorporation into engineered tissues or forced contraction …
[PDF][PDF] Human iPSC-derived natural killer cells engineered with chimeric antigen receptors enhance anti-tumor activity
Chimeric antigen receptors (CARs) significantly enhance the anti-tumor activity of immune
effector cells. Although most studies have evaluated CAR expression in T cells, here we …
effector cells. Although most studies have evaluated CAR expression in T cells, here we …
Chemically defined generation of human cardiomyocytes
Existing methods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are
efficient but require complex, undefined medium constituents that hinder further elucidation …
efficient but require complex, undefined medium constituents that hinder further elucidation …
Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney
With the prevalence of end-stage renal disease rising 8% per annum globally, there is an
urgent need for renal regenerative strategies. The kidney is a mesodermal organ that …
urgent need for renal regenerative strategies. The kidney is a mesodermal organ that …
Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells
Cardiomyocytes and endothelial cells in the heart are in close proximity and in constant
dialogue. Endothelium regulates the size of the heart, supplies oxygen to the myocardium …
dialogue. Endothelium regulates the size of the heart, supplies oxygen to the myocardium …
Principles of early human development and germ cell program from conserved model systems
Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during
weeks 2–3 of early post-implantation development. Using in vitro models of hPGC …
weeks 2–3 of early post-implantation development. Using in vitro models of hPGC …
Generation of kidney organoids from human pluripotent stem cells
The human kidney develops from four progenitor populations—nephron progenitors,
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors …
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors …
Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells
Human endothelial cells (ECs) and pericytes are of great interest for research on vascular
development and disease, as well as for future therapy. This protocol describes the efficient …
development and disease, as well as for future therapy. This protocol describes the efficient …