Base-editing mutagenesis maps alleles to tune human T cell functions
CRISPR-enabled screening is a powerful tool for the discovery of genes that control T cell
function and has nominated candidate targets for immunotherapies,,,,–. However, new …
function and has nominated candidate targets for immunotherapies,,,,–. However, new …
[HTML][HTML] A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes
R Visvanathan, T Utsuki, DE Beck, WB Clayton… - Plos one, 2024 - journals.plos.org
The activities of the phospholipase C gamma (PLCγ) 1 and 2 enzymes are essential for
numerous cellular processes. Unsurprisingly, dysregulation of PLCγ1 or PLCγ2 activity is …
numerous cellular processes. Unsurprisingly, dysregulation of PLCγ1 or PLCγ2 activity is …
[HTML][HTML] Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation
A Letafati, A Bahavar, A Tabarraei, M Norouzi… - Infectious Agents and …, 2024 - Springer
Abstract Introduction Human T-cell Lymphotropic virus type 1 (HTLV-1) belongs to
retroviridae which is connected to two major diseases, including HTLV-1-associated …
retroviridae which is connected to two major diseases, including HTLV-1-associated …
Intron retention in PI‐PLC γ1 mRNA as a key mechanism affecting MMP expression in human primary fibroblast‐like synovial cells
A Mariano, S Ammendola, A Migliorini… - Cell Biochemistry …, 2024 - Wiley Online Library
The intron retention (IR) is a phenomenon utilized by cells to allow diverse fates at the same
mRNA, leading to a different pattern of synthesis of the same protein. In this study, we …
mRNA, leading to a different pattern of synthesis of the same protein. In this study, we …
[PDF][PDF] LUMINALABREASTCANCER: INSIGHTS INTOCELLCYCLEREGULATIONAND ESTROGENSIGNALING
CL Melo - estudogeral.uc.pt
Phospholipase C gamma 1 (PLCγ1) is an essential mediator of cell signaling, activated
downstream of receptor tyrosine kinases (RTKs). Dysregulation of PLCγ1 signaling has …
downstream of receptor tyrosine kinases (RTKs). Dysregulation of PLCγ1 signaling has …