The dorsal medial prefrontal cortex (dmPFC) has been recognized as a key cortical area for
nociceptive modulation. However, the underlying neural pathway and the function of specific …

INTRODUCTION Tissue injury triggers rapid local responses coordinated by immune cells,
which dictate the maintenance and resolution of inflammation and therefore the recovery …

Medications that improve pain threshold can be useful in the pharmacotherapy of
Parkinson's disease (PD). Pain is a prevalent PD's non-motor symptom with a higher …

Nociceptive signals originating in the periphery are conveyed to the brain through specific
afferent and ascending pathways. The spino-(trigemino-) parabrachio-amygdaloid pathway …

In rodents, the amygdala has been proposed to serve as a key center for the nociceptive
perception. Previous studies have shown that extracellular signal-regulated kinase (ERK) …

Background Flavonoid monomers are proved to have an anti-inflammatory effect and may
also be promising for chronic pain treatment. In the present study, the analgesic effect and …

Aims This study investigates the anti-nociceptive and anti-inflammatory effects of new
piperazine compound (LQFM182) as well as the toxicity acute in vitro. Main methods To …

There are different animal models to evaluate pain among them the formalin hind paw assay
which is widely used since some of its events appear to be similar to the clinical pain of …

Background: Gamma-linolenic acid (GLA) is found in animals and plants that play a role in
brain function and metabolism. Objective: This study aimed to investigate the analgesic …

Nociplastic pain, the most recently proposed mechanistic descriptor of chronic pain, is the
pain resulting from an altered nociceptive system and network without clear evidence of …