Background: Uncover the pivotal link between lymphocyte-specific protein tyrosine kinase
(Lck)-related genes and clinical risk stratification in pancreatic cancer. Methods: This study …

The proto-oncogene Src is an important protein tyrosine kinase involved in signaling
pathways that control cell adhesion, growth, migration and survival. Here, we investigated …

The BCR-ABL1 oncogene is a tyrosine kinase that activates many signaling pathways,
resulting in the induction of chronic myeloid leukemia (CML). Kinase inhibitors, such as …

The binding of the lymphocyte specific protein tyrosine kinase (Lck) to T cell co-receptors is
required for T cell development and activation. In mammals, Lck initiates signal transduction …

While both lck and fyn are essential to generating the full sequelae of proximal signals
emanating from the TcR/CD3 complex, thus far, modeling the temporal and spatial …

Proteins of the ephrin-B group operate in nonlymphoid cells through the control of their
migration and attachment, and are crucial for the development of the vascular, lymphatic …

During thymocyte development, signals through the pre-T-cell receptor induce proliferation
and differentiation at early stages of maturation; thereafter, signals through the αβ T-cell …

Porcine reproductive and respiratory syndrome virus (PRRSV) causes an economically
important global swine disease, and has a complicated virus–host immunomodulation that …

Autoreactive T cells can be induced by altered peptide ligands to switch Th1 and Th2
phenotypes. The underlying molecular mechanism is critical for understanding of activation …

Background: Use of synthetic short interfering RNAs (siRNAs) to study gene function has
been limited by an inability to selectively analyze subsets of cells in complex populations …