The concept of mismatch repair (MMR) was formulated independently in 1964 to explain the
removal of brominated nucleotides from DNA as well as gene conversion during genetic …

Mutations are rare events, occurring spontaneously at a frequency of 1 per 109-1010 base
pairs per cell division. 1, 2 Nucleotide misincorporation during DNA synthesis yields …

Antibiotic resistance is often the result of mutations that block drug activity; however, bacteria
also evade antibiotics by transiently expressing genes such as multidrug efflux pumps. A …

Methods to enhance random mutagenesis in cells offer advantages over in vitro
mutagenesis, but current in vivo methods suffer from a lack of control, genomic instability …

DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from
bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes …

▪ Abstract Mismatch repair (MMR) systems play a central role in promoting genetic stability
by repairing DNA replication errors, inhibiting recombination between non-identical DNA …

Homologous recombination (HR) and mismatch repair (MMR) are inextricably linked. HR
pairs homologous chromosomes before meiosis I and is ultimately responsible for …

The mechanism of DNA mismatch repair has been modeled upon biochemical studies of the
E. coli DNA adenine methylation–instructed pathway where the initial recognition of …

DNA mismatch repair (MMR) is a highly conserved genome stabilizing pathway that corrects
DNA replication errors, limits chromosomal rearrangements, and mediates the cellular …

The tobacco N gene is a member of the Toll-interleukin-1 receptor/nucleotide-binding
site/leucine-rich repeat (TIR-NBS-LRR) class of plant resistance (R) genes and confers …