Somatic mutations contribute to cancer development by altering the activity of enhancers. In
the study, a total of 135 mutation-driven enhancers, which displayed significant chromatin …

The transcription factor SOX18 has been shown to play a crucial role in lung cancer
progression and metastasis. In this study, we investigated the effect of Sm4, a SOX18 …

The developing central nervous system (CNS) is particularly prone to malignant
transformation, but the underlying mechanisms remain unresolved. However, periods of …

Abstract Cyclin dependent kinase 7 (CDK7) plays a double role as it activates several other
cyclin dependent kinases and participates to the initiation of transcription. This kinase is …

Pseudogenes exert potential functions in tumorigenicity and tumour process in human
beings. In our previous research on oncogene AKR1B10 in hepatocellular carcinoma …

Searching for the novel tumour biomarkers is pressing for gastric cancer diagnostication and
prognostication. The serum specimens from patients diagnosed with locally advanced …

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and its associated
proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing …

The function of Sex‐determining Region Y (SRY)‐related high‐mobility‐group box (Sox)
family of transcription factors in cell fate decisions during embryonic development are well …

Simple Summary Tumor classification based on genomic features may be able to identify
new clinically relevant subtypes and disease characteristics. By integrating multiple levels of …

SRY (sex-determining region Y)-box 13 (Sox13), a member of group D of the SRY-related
high mobility group (HMG) box (Sox) family, is a critical regulator of embryonic development …