Are reactive oxygen species always detrimental to pathogens?
Reactive oxygen species (ROS) are deadly weapons used by phagocytes and other cell
types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by …
types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by …
[HTML][HTML] An overview on the therapeutics of neglected infectious diseases—Leishmaniasis and Chagas diseases
K Chanda - Frontiers in Chemistry, 2021 - frontiersin.org
Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …
Microbial antioxidant defense enzymes
C Staerck, A Gastebois, P Vandeputte, A Calenda… - Microbial …, 2017 - Elsevier
Free radicals are often described as chemical compounds characterized by unpaired
electrons in their outer orbital rendering them highly reactive species. In mammalians …
electrons in their outer orbital rendering them highly reactive species. In mammalians …
[HTML][HTML] Evasion of the immune response by Trypanosoma cruzi during acute infection
MS Cardoso, JL Reis-Cunha… - Frontiers in …, 2016 - frontiersin.org
Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical disease
that affects millions of people mainly in Latin America. To establish a life-long infection, T …
that affects millions of people mainly in Latin America. To establish a life-long infection, T …
[HTML][HTML] ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart
The activation of macrophage respiratory burst in response to infection with Trypanosoma
cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen …
cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen …
Current advances in drug discovery for Chagas disease
CB Scarim, DH Jornada, RC Chelucci… - European journal of …, 2018 - Elsevier
Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …
[HTML][HTML] Reactive species and pathogen antioxidant networks during phagocytosis
L Piacenza, M Trujillo, R Radi - Journal of Experimental Medicine, 2019 - rupress.org
The generation of phagosomal cytotoxic reactive species (ie, free radicals and oxidants) by
activated macrophages and neutrophils is a crucial process for the control of intracellular …
activated macrophages and neutrophils is a crucial process for the control of intracellular …
The double‐edged sword in pathogenic trypanosomatids: the pivotal role of mitochondria in oxidative stress and bioenergetics
RFS Menna-Barreto… - BioMed research …, 2014 - Wiley Online Library
The pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania
spp. are the causative agents of African trypanosomiasis, Chagas disease, and …
spp. are the causative agents of African trypanosomiasis, Chagas disease, and …
[HTML][HTML] A Review on the Immunological Response against Trypanosoma cruzi
Chagas disease is a chronic systemic infection transmitted by Trypanosoma cruzi. Its life
cycle consists of different stages in vector insects and host mammals. Trypanosoma cruzi …
cycle consists of different stages in vector insects and host mammals. Trypanosoma cruzi …
[HTML][HTML] Gene expression during zombie ant biting behavior reflects the complexity underlying fungal parasitic behavioral manipulation
Background Adaptive manipulation of animal behavior by parasites functions to increase
parasite transmission through changes in host behavior. These changes can range from …
parasite transmission through changes in host behavior. These changes can range from …