Introduction: Chemotherapy of malaria has become a rapidly changing field. Less than two
decades ago, treatment regimens were increasingly bound to fail due to emerging drug …

Background. Artemisinin-based combination therapies are now widely recommended as first-
line treatment for uncomplicated malaria. However, which therapies are optimal is a matter …

Malaria parasite infection continues to inflict extensive morbidity and mortality in resource-
poor countries. The insufficiently understood parasite biology, continuously evolving drug …

Background. In treating malaria in Uganda, artemether-lumefantrine (AL) has been
associated with a lower risk of recurrent parasitemia, compared with artesunate …

Background Individual patient data (IPD) meta‐analysis is the gold standard. Aggregate
data (AD) and IPD can be combined using conventional pairwise meta‐analysis when IPD …

Abstract Current World Health Organization (WHO) guidelines for the treatment of
uncomplicated falciparum malaria recommend the use of artemisinin-based combination …

Abstract Background Artesunate-amodiaquine (AS+ AQ) and artemether-lumefantrine (AM-
L) are efficacious artemisinin combination therapy (ACT) regimens that have been widely …

Background Artemisinin-based combination regimens are widely advocated for malarial
treatment, but other effective regimens might be cheaper and more readily available. Our …

Background Artesunate and amodiaquine (AS&AQ) is at present the world's second most
widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the …

Abstract Background The majority of Plasmodium falciparum malaria cases in Africa are
treated with the artemisinin combination therapies artemether-lumefantrine (AL) and …