The role of lysosomes in metabolic and autoimmune diseases
F Gros, S Muller - Nature Reviews Nephrology, 2023 - nature.com
Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …
constituents through autophagy and of extracellular components through endocytosis …
Antifibrotic agents for the management of CKD: a review
Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and a potential therapeutic
target. However, there are conceptual and practical challenges to directly targeting kidney …
target. However, there are conceptual and practical challenges to directly targeting kidney …
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules
Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis
remains elusive, hindering the development of novel therapeutics. In this study, we used …
remains elusive, hindering the development of novel therapeutics. In this study, we used …
Functional characterization of human genomic variation linked to polygenic diseases
The burden of human disease lies predominantly in polygenic diseases. Since the early
2000s, genome-wide association studies (GWAS) have identified genetic variants and loci …
2000s, genome-wide association studies (GWAS) have identified genetic variants and loci …
Transcriptome-and proteome-wide association studies nominate determinants of kidney function and damage
Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
Activation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis
L Xie, Y Cheng, W Du, L Fu, Z Wei, Y Guan… - Cell Death & …, 2023 - nature.com
Numerous studies have proven the critical role of macrophages in the renal fibrosis process.
Notably, G Protein-coupled Estrogen Receptor 1 (GPER1), a novel estrogen receptor, has …
Notably, G Protein-coupled Estrogen Receptor 1 (GPER1), a novel estrogen receptor, has …
[HTML][HTML] Mechanisms of ferroptosis in chronic kidney disease
WQ Zhuo, Y Wen, HJ Luo, ZL Luo… - Frontiers in Molecular …, 2022 - frontiersin.org
Ferroptosis is a newly identified form of regulated cell death characterized by iron
accumulation and lipid peroxidation. Ferroptosis plays an essential role in the pathology of …
accumulation and lipid peroxidation. Ferroptosis plays an essential role in the pathology of …
[HTML][HTML] Mapping of the gene network that regulates glycan clock of ageing
Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its
structure and function. However, regulatory mechanisms behind this complex …
structure and function. However, regulatory mechanisms behind this complex …
Gaining insight into metabolic diseases from human genetic discoveries
M Claussnitzer, K Susztak - Trends in Genetics, 2021 - cell.com
Human large-scale genetic association studies have identified sequence variations at
thousands of genetic risk loci that are more common in patients with diverse metabolic …
thousands of genetic risk loci that are more common in patients with diverse metabolic …