Aging is characterized generally by progressive and overall physiological decline of
functions and is observed in all animals. A long line of evidence has established the …

Both the neuropsychiatric syndrome of apathy and major depressive disorder comprise a
heterogenous cluster of symptoms which span multiple behavioural domains. Despite this …

The glucocorticoid (GC) hypothesis posits that effects of stress and dysregulated
hypothalamic-pituitary-adrenal axis activity accumulate over the lifespan and contribute to …

Rationale Motivational deficits are a common symptom shared across multiple psychiatric
and neurodegenerative disorders. Effort-based decision-making tasks are a translatable …

Enrichment has become a key aspect of captive husbandry practices as a means of
improving animal welfare by increasing environmental stimuli. However, the enrichment …

Aging is the greatest risk factor for the development of neurodegenerative diseases, yet we
still do not understand how the aging process leads to pathologic vulnerability. The research …

Alterations in neural pathways that regulate appetitive motivation may contribute to
increased obesity risk in offspring born to mothers fed a high fat (HF) diet. However, current …

Disorders of motivation such as apathy syndrome are highly prevalent across neurological
disorders but do not yet have an agreed treatment approach. The use of translational …

Agitation, which comprises verbal or physical aggression and hyperactivity, is one of the
most frequent neuropsychiatric symptoms observed in patients with Alzheimer's disease …

Apathy is a complex psychiatric syndrome characterised by motivational deficit, emotional
blunting and cognitive changes. It occurs alongside a broad range of neurological disorders …