[HTML][HTML] SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial …

Y Song, W Geng, D Zhu, H Liang, Z Du, B Tong… - Free Radical Biology …, 2024 - Elsevier
Nucleus pulposus (NP) cell function-loss is one main contributor during intervertebral disc
degeneration (IDD) progression. Both mitochondria and endoplasmic reticulum (ER) play …

NLRX1 Inhibits LPS-Induced Microglial Death via Inducing p62-Dependent HO-1 Expression, Inhibiting MLKL and Activating PARP-1

YL Huang, DY Huang, V Klochkov, CM Chan, YS Chen… - Antioxidants, 2024 - mdpi.com
The activation of microglia and the production of cytokines are key factors contributing to
progressive neurodegeneration. Despite the well-recognized neuronal programmed cell …

Identifying differentially expressed genes in goat mammary epithelial cells induced by overexpression of SOCS3 gene using RNA sequencing

N Song, C Ma, Y Guo, S Cui, S Chen… - Frontiers in Veterinary …, 2024 - frontiersin.org
The suppressor of cytokine signaling 3 (SOCS3) is a key signaling molecule that regulates
milk synthesis in dairy livestock. However, the molecular mechanism by which SOCS3 …

MicroRNA transcriptome analysis reveals the immune regulatory mechanism of Crassostrea hongkongesis against Vibrio harveyi infection

Y Hou, T Liao, F Zhang, T Zhang, L Wang, W Lv… - Fish & Shellfish …, 2024 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNA molecules that modulate target-genes
expression and play crucial roles in post-transcriptional regulation and immune system …

[HTML][HTML] Evolutionary edge: NOD-like receptors in immunity

AA Kattner - Biomedical Journal, 2024 - Elsevier
This issue of the Biomedical Journal delves into the multifaceted roles of NOD-like receptors
(NLRs) in immunity, examining their subfamilies and functions within innate and adaptive …

Mitochondrial quality control pathways sense mitochondrial protein import

LP Lee-Glover, TE Shutt - Trends in Endocrinology & Metabolism, 2024 - cell.com
Mitochondrial quality control (MQC) mechanisms are required to maintain a functional
proteome, which enables mitochondria to perform a myriad of important cellular functions …