Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), which is thought to result from immune-mediated inflammatory disorders, leads to high …

The endocannabinoid system (ECS) is involved in many physiological processes and has
been suggested to play a critical role in the immune response and the central nervous …

While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced
obesity (DIO), its relative role in different cell types has not been tested. The current study …

Background Crohn's disease is an idiopathic inflammatory process that is occasionally
associated with complications, which cause significant morbidity and mortality. The anti …

Exocannabinoids such as tetrahydrocannabinol (THC) may alter the physiological function
of endocannabinoids in male reproduction and thus affect male fertility. This study aimed to …

The endocannabinoid system, particularly cannabinoid receptor 2 (CB2 in mice and CNR2
in humans), has controversial pathophysiological implications in colon cancer. Here, we …

The use of cannabinoids for the treatment of chronic diseases has increased in the United
States, with 23 states having legalized the use of marijuana. Although currently available …

Sepsis and septic shock are still one of the most important medical challenges. Sepsis is an
extreme and uncontrolled response of the innate immune system to invading pathogenesis …

Ulcerative colitis (UC) is a chronic inflammatory condition that until this date, lacks curative
treatments. Previously, synthetic selective CB2 receptor (CB2R) agonists demonstrated …

The CB2 cannabinoid receptor has been implicated in the regulation of intestinal
inflammation. Following on from the promising activity of a series of 4-oxo-1, 4 …