Background: It has been proposed that halogenated anaesthetics interfere with the
endotheliumdependent circulatory control by attenuating the effects of endothelium …

This review takes a focused bedside to bench back to bedside approach to assess the issue
of endothelial dysfunction in advanced liver disease. We start with a patient presentation of …

Cirrhosis predisposes the liver to secondary stresses such as endotoxemia possibly via
dysregulation of the hepatic portal circulation secondary to imbalanced upregulation of …

When hepatic stellate cells (Ito cells, fat-storing cells) were incubated with adrenomedullin,
they underwent relaxation as monitored by the silicone-rubber membrane method; 43 …

Portal hypertension, a common consequence of chronic liver diseases, is directly
responsible for most complications of cirrhosis. In liver microcirculation, nitric oxide is …

Limited data exist regarding morphogenesis and differentiation during liver regeneration.
We examined the role of epimorphin on liver regeneration. After 70% partial hepatectomy …

Our pilot study disclosed that tryptase-positive mast cells (MC) were densely distributed
around the intrahepatic bile ducts (peribiliary MC). In this study, the pathophysiologic roles of …

NI 1988, Y~ agisawa et ai. isolated a potent vasoconstricting peptide from the supematant of
bovine endotheiial ceils, and named it endotbeiin-1 (ET-1)(1). Besides vasoregulatory …

Background CD4+ T cells play a critical role during hepatic ischemia-reperfusion (I/R) injury
although the mechanisms of their migration in the postischemic liver remain unclear. We …

The most successful approach for restoring normal long-term glucose homeostasis in type I
diabetes mellitus is whole-organ pancreas transplantation. Graft pancreatitis is observed in …