Background/Aim: Endothelin-1 plays an important role in the regulation of portal
hypertension; endothelin antagonists have been extensively studied in portal hypertensive …

Abstract Background and Aim: Partial portal vein ligation (PPVL) is a commonly used
procedure to induce prehepatic portal hypertension in animal models. The aim of this study …

We studied the effect of lipopolysaccharide (LPS) on the proliferation of culturestimulated
rat stellate cells. DNA synthesis as determined by [3H]thymidine incorporation was …

В данном обзоре литературы представлены клеточные и молекулярные механизмы
повреждения печени при сепсисе. В процессе сепсиса печень играет ведущую роль в …

This study addresses the microvascular mechanisms by which a remote, mild stress such as
blunt trauma sensitizes the liver to injury. Rats received closed femur fracture (FFx), and 24 h …

Abnormalities of arterial oxygenation are common in patients with cirrhosis and a widened
alveolar-arterial oxygen gradient is reported in more than half of these patients at pre …

BACKGROUND AND AIM: The aim of this study was to estimate the serum levels of
endothelin-1 (ET-1) and nitric oxide (NO) and to analyze the correlation of their levels with …

The mechanisms that regulate vascular resistance in the liver are an area of active
investigation. Previously, we have shown that nitric oxide (NO) modulates hepatic vascular …

The nonselective endothelin (ET) receptor antagonist bosentan has been shown to restore
systemic and gut oxygen delivery and reverse intestinal mucosal acidosis in porcine …

Hepatic stellate cells (HSC) wrap out around hepatic sinusoids, and recent studies have
shown that they contract or relax in response to vasoactive mediators suggesting that they …