[HTML][HTML] Circadian rhythm dysregulation and restoration: the role of melatonin

C Vasey, J McBride, K Penta - Nutrients, 2021 - mdpi.com
Sleep is an essential component of overall human health but is so tightly regulated that
when disrupted can cause or worsen certain ailments. An important part of this process is …

[HTML][HTML] Tryptophan metabolism and gut-brain homeostasis

W Roth, K Zadeh, R Vekariya, Y Ge… - International journal of …, 2021 - mdpi.com
Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

Structural insights into the lipid and ligand regulation of serotonin receptors

P Xu, S Huang, H Zhang, C Mao, XE Zhou, X Cheng… - Nature, 2021 - nature.com
Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is an important neurotransmitter, that
activates the largest subtype family of G-protein-coupled receptors. Drugs that target 5 …

[HTML][HTML] Role of gut microbiome in autism spectrum disorder and its therapeutic regulation

MA Taniya, HJ Chung, A Al Mamun, S Alam… - Frontiers in cellular …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a neurological disorder that affects normal brain
development. The recent finding of the microbiota–gut–brain axis indicates the bidirectional …

Electrochemical biosensors based on polymer nanocomposites for detecting breast cancer: Recent progress and future prospects

A Mohammadpour-Haratbar, Y Zare… - Advances in Colloid and …, 2022 - Elsevier
In recent years, the second-highest mortality rate of any cancer worldwide has been breast
cancer (BC), which is one of the three most common and deadly cancers among women …

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

SM O'Mahony, G Clarke, YE Borre, TG Dinan… - Behavioural brain …, 2015 - Elsevier
The brain-gut axis is a bidirectional communication system between the central nervous
system and the gastrointestinal tract. Serotonin functions as a key neurotransmitter at both …

2022 WSAVA guidelines for the recognition, assessment and treatment of pain

BP Monteiro, BDX Lascelles, J Murrell… - Journal of Small …, 2023 - Wiley Online Library
Animal sentience refers to the capacity of animals to feel both positive and negative
emotions including that of pain. As veterinary health professionals, we have a medical and …

Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics

AM Jaster, J González-Maeso - Molecular psychiatry, 2023 - nature.com
Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models

MA Schneider, L Heeb, MM Beffinger… - Science translational …, 2021 - science.org
Platelet-derived peripheral serotonin has pleiotropic effects on coagulation, metabolism,
tissue regeneration, and cancer growth; however, the effect of serotonin on the tumor …

The role of serotonin and its receptors in activation of immune responses and inflammation

MS Shajib, WI Khan - Acta physiologica, 2015 - Wiley Online Library
Abstract Serotonin or 5‐hydroxytryptamine (5‐HT) is a neurotransmitter and hormone that
contributes to the regulation of various physiological functions by its actions in the central …