Disrupted protein folding or decreased protein stability can lead to the accumulation of
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …

The number of biological therapeutic agents in the clinic and development pipeline has
increased dramatically over the last decade and the number will undoubtedly continue to …

Protein aggregation has been recognized as one of the major challenges in the
development and commercialization of successful protein-based drug products because of …

Antibody-based proteins have become an important class of biologic therapeutics, due in
large part to the stability, specificity, and adaptability of the antibody framework. Indeed …

Chemotherapy is one of the major therapeutic options for cancer treatment. Chemotherapy
is often associated with a low therapeutic window due to its poor specificity towards tumor …

Real‐time monitoring of bioprocesses by the integration of analytics at critical unit
operations is one of the paramount necessities for quality by design manufacturing and real …

Oral inhalation is the preferred route for delivery of small molecules to the lungs, because
high tissue levels can be achieved shortly after application. Biologics are mainly …

This review highlights how hydrogel formulations can improve intravitreal protein delivery to
the posterior segment of the eye in order to increase therapeutic outcome and patient …

The convenience of subcutaneous (SC) administration and the increasing interest in
monoclonal antibody (mAb)-based therapies for chronic diseases, hint their potential for SC …

Protein aggregation in biotherapeutics has been identified to increase immunogenicity,
leading to immune-mediated adverse effects, such as severe allergic responses including …