Regulation of renin: new evidence from cultured cells and genetically modified mice
M Bader, D Ganten - Journal of Molecular Medicine, 2000 - Springer
Renin, as the rate-limiting enzyme in the synthesis of the potent vasoactive peptide
angiotensin II, has been studied for more than 100 years. Transgenic and knockout mice for …
angiotensin II, has been studied for more than 100 years. Transgenic and knockout mice for …
The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes
RL Davisson, G Yang, TG Beltz, MD Cassell… - Circulation …, 1998 - Am Heart Assoc
We have previously shown that mice transgenic for both the human renin and human
angiotensinogen genes (RA+) exhibit appropriate tissue-and cell-specific expression of both …
angiotensinogen genes (RA+) exhibit appropriate tissue-and cell-specific expression of both …
Glia-and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference
S Morimoto, MD Cassell, CD Sigmund - Journal of Biological Chemistry, 2002 - ASBMB
The purpose of this study is to examine the regulation of blood pressure and fluid and
electrolyte homeostasis in mice overexpressing angiotensin II (Ang-II) in the brain and to …
electrolyte homeostasis in mice overexpressing angiotensin II (Ang-II) in the brain and to …
Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation
PL SINN, CD SIGMUND - Physiological genomics, 2000 - journals.physiology.org
Sinn, Patrick L., and Curt D. Sigmund. Identification of three human renin mRNA isoforms
from alternative tissue-specific transcriptional initiation. Physiol Genomics 3: 25–31, 2000 …
from alternative tissue-specific transcriptional initiation. Physiol Genomics 3: 25–31, 2000 …
Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule
JL Lavoie, KD Lake-Bruse… - American Journal of …, 2004 - journals.physiology.org
The purpose of this study was to evaluate the physiological significance of a tissue renin-
angiotensin system in the proximal tubule of the kidney. To accomplish this, we produced …
angiotensin system in the proximal tubule of the kidney. To accomplish this, we produced …
Angiotensin mutant mice: a focus on the brain renin-angiotensin system
S Morimoto, CD Sigmund - Neuropeptides, 2002 - Elsevier
With advances in genetic manipulation and molecular biological and physiological
techniques, the mouse has become the animal model of choice for studying the genetic …
techniques, the mouse has become the animal model of choice for studying the genetic …
Evidence supporting a functional role for intracellular renin in the brain
JL Lavoie, X Liu, RA Bianco, TG Beltz, AK Johnson… - …, 2006 - Am Heart Assoc
The brain renin–angiotensin system is implicated in the regulation of blood pressure (BP)
and fluid homeostasis. Recent studies reveal that 2 forms of renin are expressed in the brain …
and fluid homeostasis. Recent studies reveal that 2 forms of renin are expressed in the brain …
Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen …
RL Davisson, HS Kim, JH Krege… - The Journal of …, 1997 - Am Soc Clin Investig
The aim of this study was to determine whether elements of the human renin-angiotensin
system (RAS) could functionally replace elements of the mouse RAS by complementing the …
system (RAS) could functionally replace elements of the mouse RAS by complementing the …
The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene
S Morimoto, MD Cassell, CD Sigmund - Circulation research, 2002 - Am Heart Assoc
We previously reported the generation of 2 novel transgenic mouse models containing the
human renin (hREN) gene encoded on P1 artificial chromosomes (PAC) containing large …
human renin (hREN) gene encoded on P1 artificial chromosomes (PAC) containing large …
Nonimmune hydrops fetalis and activation of the renin-angiotensin system after asphyxia in preterm fetal sheep
ER Lumbers, AJ Gunn, DY Zhang… - American Journal …, 2001 - journals.physiology.org
This study examined the hypothesis that the development of hydrops fetalis after asphyxia in
the 0.6 gestation sheep fetus would be associated with activation of the fetal renin …
the 0.6 gestation sheep fetus would be associated with activation of the fetal renin …