Renin, as the rate-limiting enzyme in the synthesis of the potent vasoactive peptide
angiotensin II, has been studied for more than 100 years. Transgenic and knockout mice for …

We have previously shown that mice transgenic for both the human renin and human
angiotensinogen genes (RA+) exhibit appropriate tissue-and cell-specific expression of both …

The purpose of this study is to examine the regulation of blood pressure and fluid and
electrolyte homeostasis in mice overexpressing angiotensin II (Ang-II) in the brain and to …

Sinn, Patrick L., and Curt D. Sigmund. Identification of three human renin mRNA isoforms
from alternative tissue-specific transcriptional initiation. Physiol Genomics 3: 25–31, 2000 …

The purpose of this study was to evaluate the physiological significance of a tissue renin-
angiotensin system in the proximal tubule of the kidney. To accomplish this, we produced …

With advances in genetic manipulation and molecular biological and physiological
techniques, the mouse has become the animal model of choice for studying the genetic …

The brain renin–angiotensin system is implicated in the regulation of blood pressure (BP)
and fluid homeostasis. Recent studies reveal that 2 forms of renin are expressed in the brain …

The aim of this study was to determine whether elements of the human renin-angiotensin
system (RAS) could functionally replace elements of the mouse RAS by complementing the …

We previously reported the generation of 2 novel transgenic mouse models containing the
human renin (hREN) gene encoded on P1 artificial chromosomes (PAC) containing large …

This study examined the hypothesis that the development of hydrops fetalis after asphyxia in
the 0.6 gestation sheep fetus would be associated with activation of the fetal renin …