The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …

The analysis of peptides and proteins as well as the grander scope of proteomics (large
scale study of proteins) has been advanced by the development of a versatile array of ion …

Proteins are composed exclusively of l-amino acids. Among elderly individuals, however, d-
aspartic acid (d-Asp) residues have been found in eye lens and brain, as well as in other …

Isomeric peptide analyses are an analytical challenge of great importance to therapeutic
monoclonal antibody and other biotherapeutic product development workflows. Aspartic …

While α-linked amino acids in the L-form are exclusively utilized in mammalian protein
building, β-linked and D-form amino acids also have important biological roles …

Despite extensive efforts on probing the mechanism of Alzheimer's disease (AD) and
enormous investments into AD drug development, the lack of effective disease-modifying …

Spontaneous chemical modifications play an important role in human disease and aging at
the molecular level. Deamidation and isomerization are known to be among the most …

An indirect competitive binding mechanism can be exploited to allow a combination of
cationic fluorophores and water-soluble synthetic receptors to selectively recognize and …

Background Age-related cataracts, which probably form due to insolubilization of lens
proteins, can lead to loss of vision. Although the exact reason is unknown, lens protein …

The l-to d-amino acid residue isomerization of neuropeptides is an understudied post-
translational modification found in animals across several phyla. Despite its physiological …