Antibiotic resistance has become a pressing global health crisis, with bacterial infections
increasingly difficult to treat due to the emergence of multidrug resistance. This study aims to …

The cases of bacterial multidrug resistance are increasing every year and becoming a
serious concern for human health. Multidrug efflux pumps are key players in the formation of …

Obesity, characterized by excessive fat accumulation, is a major health concern. Inhibition of
human pancreatic lipase, an enzyme involved in fat digestion, offers a potential strategy for …

Fungal histone deacetylases (HDACs) are enzymes known for their crucial role in gene
expression regulation through histone deacetylation, leading to chromatin compaction and …

A series of novel 24 phenylhydrazono phenoxyquinoline derivatives were synthesized with
moderate to excellent yield and screened for their efficacy against the α-amylase enzyme …

Antibiotic resistance is a pressing global health challenge, driven in part by the remarkable
efflux capabilities of efflux pump in AcrB (Acriflavine Resistance Protein B) protein in Gram …

Abstract Decaprenylphosphoryl-β-D-ribose-2′-epimerase (DprE1), a crucial enzyme in the
process of arabinogalactan and lipoarabinomannan biosynthesis, has become the target of …

This study investigates the anti-cancer potential of recently discovered indole alkaloids from
Nauclea Officinalis against third and fourth-generation EGFR mutations using computational …

The present study reports the synthesis of sulphonamide-azaheterocycle conjugates (3 aj)
and evaluates its in vitro anticancer activity against breast cancer cell line (MCF-7) and liver …

Objective: Wound healing remains a complex biological process crucial for tissue repair and
homeostasis. Our goal in this paper is to focus on the application of advanced computational …