The functional interplay between the t (9; 22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia
A Rafiei, AA Mian, C Doering, A Metodieva… - PLoS …, 2015 - journals.plos.org
The hallmark of Philadelphia chromosome positive (Ph+) leukemia is the BCR/ABL kinase,
which is successfully targeted by selective ATP competitors. However, inhibition of BCR/ABL …
which is successfully targeted by selective ATP competitors. However, inhibition of BCR/ABL …
Frequencies of BCR:: ABL1 Transcripts in Patients with Chronic Myeloid Leukemia: A Meta-Analysis
P Romero-Morelos, AL González-Yebra… - Genes, 2024 - mdpi.com
Chronic myeloid leukemia (CML) is associated with the Philadelphia chromosome and
distinct BCR:: ABL1 gene transcripts. We assessed the frequencies of these transcripts in …
distinct BCR:: ABL1 gene transcripts. We assessed the frequencies of these transcripts in …
Distribution of BCR:: ABL1 Transcripts in the Different Clinical Phases of Chronic Myeloid Leukemia: Effect on Hematological Parameters and Patient Survival
P Romero-Morelos, AL González-Yebra… - Genes, 2024 - mdpi.com
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder characterized by the
presence of the Philadelphia chromosome, a product of the reciprocal translocation t (9; …
presence of the Philadelphia chromosome, a product of the reciprocal translocation t (9; …
Masked Philadelphia chromosome due to atypical BCR/ABL localization on the 9q34 band and duplication of the der (9) in a case of chronic myelogenous leukemia
G Fugazza, A Garuti, S Marchelli, M Miglino… - Cancer genetics and …, 2005 - Elsevier
The cytogenetic studies and molecular evaluation of a Philadelphia chromosome negative
chronic myelogenous leukemia patient with trisomy 21 (100% metaphases) and trisomy 9 …
chronic myelogenous leukemia patient with trisomy 21 (100% metaphases) and trisomy 9 …
Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders
C Walz, NCP Cross, RA Van Etten, A Reiter - Leukemia, 2008 - nature.com
Constitutively activated mutants of the non-receptor tyrosine kinases (TK) ABL1 (Abelson
murine leukemia viral (v-abl) homolog (1) protein) and JAK2 (JAnus Kinase 2 or Just …
murine leukemia viral (v-abl) homolog (1) protein) and JAK2 (JAnus Kinase 2 or Just …
Chronic myeloid leukemia
T Fioretos - … and Molecular Genetic Aberrations of Tumor Cells, 2015 - Wiley Online Library
Chronic myeloid leukemia (CML) is a clonal bone marrow (BM) disease characterized by
neoplastic overproduction of, mainly, granulocytes. The treatment of CML has changed …
neoplastic overproduction of, mainly, granulocytes. The treatment of CML has changed …
Myelodysplastic syndromes, chronic myeloproliferative diseases, and myelodysplastic/myeloproliferative diseases
JW Vardiman - Seminars in diagnostic pathology, 2003 - Elsevier
This article reviews the major diagnostic criteria for the myelodysplastic syndromes, chronic
myeloproliferative diseases, and myelodysplastic/myeloproliferative diseases. Perhaps the …
myeloproliferative diseases, and myelodysplastic/myeloproliferative diseases. Perhaps the …
Impact of chromosomal rearrangement upon DNA methylation patterns in leukemia
HM Byun, S Eshaghian, D Douer, J Trent… - Open …, 2017 - degruyter.com
Genomic instability, including genetic mutations and chromosomal rearrangements, can
lead to cancer development. Aberrant DNA methylation occurs commonly in cancer cells …
lead to cancer development. Aberrant DNA methylation occurs commonly in cancer cells …
[HTML][HTML] 1, 3-Butadiene metabolite 1, 2, 3, 4 diepoxybutane induces DNA adducts and micronuclei but not t (9; 22) translocations in human cells
VE Walker, A Degner, EW Carter, JA Nicklas… - Chemico-biological …, 2019 - Elsevier
Abstract Epidemiological studies of 1, 3-butadiene (BD) exposures have reported a possible
association with chronic myelogenous leukemia (CML), which is defined by the presence of …
association with chronic myelogenous leukemia (CML), which is defined by the presence of …
[PDF][PDF] A mathematical model of BCR-ABL autophosphorylation, signaling through the CRKL pathway, and gleevec dynamics in chronic myeloid leukemia
A mathematical model is presented that describes several signaling events that occur in
cells from patients with chronic myeloid leukemia, ie autophosphorylation of the Bcr-Abl …
cells from patients with chronic myeloid leukemia, ie autophosphorylation of the Bcr-Abl …