The virtually obligatory presence of the Philadelphia chromosome may suggest a causal
homogeneity, but chronic myelogenous leukemia (CML) is a clinically heterogeneous …

Advances in defining the mutational landscape of myeloproliferative neoplasms (MPNs)
over the past decade have revolutionized the molecular diagnosis of these entities …

The myeloproliferative disorders (MPD) and myelodysplastic syndromes (MDS) encompass
a pathologically and clinically heterogeneous group of hematologic entities that are united …

Acquired constitutive activation of protein tyrosine kinases is a central feature of
myeloproliferative disorders, including BCR-ABL-negative chronic myeloid leukaemia …

Chronic Myeloid Leukaemia (CML) is a clonal myeloproliferative disorder characterized by a
shortened chromosome 22 known as the Philadelphia chromosome (Ph). As the main …

Amaç: Çalışmamızda 25 KML (Kronik Miyeloid Lösemi) hastasında Sitogenetik Analiz ve RT-
PCR (Reverse Transcriptase Polymerase Chain Reaction) Tekniği ile Ph (Philadelphia) …

Dermatologist's opinion is often sought for various types of drug reactions/side effects-
specially, if the effects are on skin, mucous membranes or genitals. Updating their …

Abstract Background: t (9; 22) is a balanced translocation, and the chromosome 22
breakpoints (Philadelphia chromosome–Ph+) determine formation of different fusion genes …

Objective Hematological malignancies are neoplasms of bone marrow-derived cells.
Epidemiological and clinical studies show that the mutations occurring in somatic cells …

Chronic myeloid leukemia (CML) was the first human malignancy to be associated with a
specific genetic lesion, the Philadelphia chromosome, harboring the BCR-ABL oncogene …