Besides their main function for energy production in form of ATP in processes of oxidative
phosphorylation (OxPhos), mitochondria perform many other important cellular functions …

With global population aging, age-related diseases, especially sarcopenia, have attracted
much attention in recent years. Characterized by low muscle strength, low muscle quantity or …

Muscle fatigue is defined as a decrease in maximal force or power generated in response to
contractile activity, and it is a risk factor for the development of musculoskeletal injuries. One …

Duchenne muscular dystrophy (DMD) is a progressive disease caused by the loss of
function of the protein dystrophin. This protein contributes to the stabilisation of striated cells …

Peroxiredoxins are multifunctional enzymes that play a key role in protecting cells from
stresses and maintaining the homeostasis of many cellular processes. Peroxiredoxins were …

Muscle weakness associated with sarcopenia is a major contributor to reduced health span
and quality of life in the elderly. However, the underlying mechanisms of muscle weakness …

Significance: Cancer is frequently associated with the early appearance of cachexia, a
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …

Loss of innervation is a key driver of age associated muscle atrophy and weakness
(sarcopenia). Our laboratory has previously shown that denervation induced atrophy is …

As people age, their skeletal muscle (SkM) experiences a decline in mitochondrial
functionality and density, which leads to decreased energy production and increased …

Our laboratory previously showed lipid hydroperoxides and oxylipin levels are elevated in
response to loss of skeletal muscle innervation and are associated with muscle pathologies …