Ligation of cell surface matrix adhesion receptors such as integrins can increase expression
of specific cell cycle regulatory proteins such as cyclin A, thereby regulating cell cycle …

Publisher Summary This chapter describes protocols for extract preparation, and methods
for assessing nuclear changes of apoptosis along with more direct assays for detecting …

Activity of the independently regulated human c-myc P0 promoter has been associated with
the undifferentiated status of leukemia cells as well as the hormone-independent …

The contact of natural killer (NK) cells with foreign cells and with certain virus-infected or
tumor cells triggers the cytolytic machinery of NK cells. This triggering leads to exocytosis of …

Stable ectopic expression of Flt3 receptor tyrosine kinase is usually performed in interleukin
3 (IL-3)-dependent murine cell lines like Ba/F3, resulting in loss of IL-3 dependence. Such …

Renal cell carcinoma (RCC) responds very poorly to chemo-or radiotherapy. Renal cell
carcinoma cell lines have been described to be resistant to apoptosis-inducing stimuli and to …

The present invention relates to nine residue peptides (ApoptoM) from flavivirus M
ectodomain able to modulate specifically the apoptotic activity of diverse flavivirus, to …

The present invention relates to nine residue peptides (ApoptoM) from flavivirus M
ectodomain able to modulate specifically the apoptotic activity of diverse flavivirus, to …

ABSTRACT p53 is a potent tumor suppressor which can prevent the propagation of cells
carrying oncogenic lesions via a multitude of pathways. Besides the transactivation of …

Cyclin-dependent kinases (Cdks) are activated by cyclin binding and phosphorylation by the
Cdk-activating kinase (CAK). Activation of Cdk6 by the D-type cyclins requires …