Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-
phosphate (S1P), are produced by the metabolism and perturbation of biological …

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that regulates a variety of cellular
functions such as cell proliferation, migration, survival, calcium mobilization, cytoskeletal …

Autotaxin (ATX) is a soluble extracellular enzyme that is abundant in mammalian plasma
and cerebrospinal fluid (CSF). It has two known enzymatic activities, acting as both a …

Lysophosphatidic acid (LPA) is a potent signaling lipid, and state-dependent alterations in
plasma LPA make it a promising diagnostic marker for various diseases. However, plasma …

A number of membrane lipid-derived mediators play pivotal roles in the initiation,
maintenance, and regulation of various types of acute and chronic pain. Acute pain …

Pain associated with bone cancer remains poorly managed, and chemotherapeutic drugs
used to treat cancer usually increase pain. The discovery of dual-acting drugs that reduce …

Mass spectrometry-based lipidomics approaches offer valuable tools for the detection and
quantification of various lipid species, including sphingolipids. The present study aimed to …

Nociceptors are specialized sensory neurons that detect damaging or potentially damaging
stimuli and are found in the dorsal root (DRG) and trigeminal ganglia. These neurons are …

ABSTRACT TMEM120A (TACAN) is an enigmatic protein with several seemingly
unconnected functions. It was proposed to be an ion channel involved in sensing …

Accumulating evidence suggests that lysophospholipids (LPL) serve as lipid mediators that
exert their diverse pathophysiological functions via G protein-coupled receptors. These …