Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

The group of AGC protein kinases includes more than 60 protein kinases in the human
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …

Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite
burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on …

Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we
present class I and II aaRSs as previously unrecognized targets for adenosine 5 …

The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during
cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein …

Transmission of malaria-causing parasites to mosquitoes relies on the production of
gametocyte stages and their development into gametes. These stages display various …

Our understanding of the key phosphorylation-dependent signalling pathways in the human
malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue …

During asexual intraerythrocytic development, Plasmodium falciparum diverges from the
paradigm of the eukaryotic cell cycles by undergoing multiple rounds of DNA replication and …

Artemisinin and its derivatives (ARTs) are frontline antimalarial drugs. However, ART
monotherapy is associated with a high frequency of recrudescent infection, resulting in …

One of the hallmarks of the parasitic phylum of Apicomplexa is the presence of highly
specialised, apical secretory organelles, called the micronemes and rhoptries that play …