Cognitive impairment after surgery is a common problem, affects mainly the elderly, and can
be divided into postoperative delirium and postoperative cognitive dysfunction. Both …

Computational chemistry and structure-based design have traditionally been viewed as a
subset of tools that could aid acceleration of the drug discovery process, but were not …

Calendula officinalis L., commonly known as pot marigold, is a popular ornamental and
highly medicinal plant. In fact, it is well recognized for its wide‐ranging therapeutic effects …

To discover novel BChE inhibitors, a hierarchical virtual screening protocol followed by
biochemical evaluation was applied. The most potent compound 8012-9656 (eq BChE …

For many years, the primary focus has been on finding effective treatments for Alzheimer's
disease (AD), which has led to the identification of promising therapeutic targets. The …

In the last years, in order to achieve a better treatment of Alzheimer's disease (AD), much
focus has been put on the development of cholinesterase (Acetylcholinesterase and …

Cholinesterases catalyze the breakdown of the neurotransmitter acetylcholine (ACh), a
naturally occurring neurotransmitter, into choline and acetic acid, allowing the nervous …

Many Bangladeshi medicinal plants have been used to treat Alzheimer's disease and other
neurodegenerative diseases. In the present study, the anticholinesterase effects of eight …

In searching for a new and efficient therapeutic agent against Alzheimer's disease, a
Quantitative structure-activity relationship (QSAR) was derived for 45 Flavonoid derivatives …

Multitarget molecular hybrids of N-benzyl pyrrolidine derivatives were designed,
synthesized, and biologically evaluated for the treatment of Alzheimer's disease (AD) …