MicroRNAs in cardiac diseases

RMW Colpaert, M Calore - Cells, 2019 - mdpi.com
Since their discovery 20 years ago, microRNAs have been related to posttranscriptional
regulation of gene expression in major cardiac physiological and pathological processes …

Hypertrophic cardiomyopathy as an oligogenic disease: transcriptomic arguments

NM Baulina, IS Kiselev, OS Chumakova, OO Favorova - Molecular biology, 2020 - Springer
Hypertrophic cardiomyopathy (HCM) is the most common genetically determined heart
pathology and is often accompanied by fatal complications. Today, the traditional view of the …

Construction of a TF–miRNA–gene feed-forward loop network predicts biomarkers and potential drugs for myasthenia gravis

C Bo, H Zhang, Y Cao, X Lu, C Zhang, S Li, X Kong… - Scientific reports, 2021 - nature.com
Myasthenia gravis (MG) is an autoimmune disease and the most common type of
neuromuscular disease. Genes and miRNAs associated with MG have been widely studied; …

Profiling of exosomal microRNAs expression in umbilical cord blood from normal and preeclampsia patients

HT Pan, XL Shi, M Fang, XM Sun, PP Chen… - BMC pregnancy and …, 2022 - Springer
Background Epidemiological and experimental studies suggest that preeclampsia has a
negative impact on maternity and offspring health. Previous studies report that dysregulation …

Identification of a lncRNA‑miRNA‑mRNA network based on competitive endogenous RNA theory reveals functional lncRNAs in hypertrophic cardiomyopathy

L Tao, J Shi, X Huang, F Hua… - Experimental and …, 2020 - spandidos-publications.com
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease that affects 1 in
every 200 people in the general population, leading to cardiac ischemia, heart failure and …

Development and validation of a genomic nomogram based on a ceRNA network for comprehensive analysis of obstructive sleep apnea

W Liu, X Sun, J Huang, J Zhang, Z Liang, J Zhu… - Frontiers in …, 2023 - frontiersin.org
Objectives: Some ceRNA associated with lncRNA have been considered as possible
diagnostic and therapeutic biomarkers for obstructive sleep apnea (OSA). We intend to …

The crosstalk between STAT3 and microRNA in cardiac diseases and protection

L Wu, Z Li, Y Li - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Signal transducer and activator of transcription 3 (STAT3), an important transcription factor
and signaling molecule, play an important role in cardiac disease and protection. As a …

Integrative bioinformatics analysis reveals that Infarct‐Mediated overexpression of potential miR‐662/CREB1 pathway‐induced neuropeptide VIP is associated with …

P Zhang, B Liu - Disease Markers, 2021 - Wiley Online Library
Background. Neuropeptide levels are closely associated with the development and
maintenance of atrial fibrillation (AF) after myocardial infarction (MI). This study was aimed at …

[HTML][HTML] Hypertrophic cardiomyopathy in MYBPC3 carriers in aging

K Ananthamohan, JE Stelzer… - The journal of …, 2024 - ncbi.nlm.nih.gov
Hypertrophic cardiomyopathy (HCM) is characterized by abnormal thickening of the
myocardium, leading to arrhythmias, heart failure, and elevated risk of sudden cardiac …

Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy

A Khalilimeybodi, JJ Saucerman… - Computers in Biology and …, 2024 - Elsevier
Familial hypertrophic cardiomyopathy (HCM) is a significant precursor of heart failure and
sudden cardiac death, primarily caused by mutations in sarcomeric and structural proteins …