Comparing the pharmacokinetic and pharmacodynamic qualities of current and future therapies for uterine fibroids

G Evangelisti, F Barra, U Perrone… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Uterine fibroids are the most common benign gynecological tumors affecting
women of reproductive ages. Although surgery is the definitive treatment choice, several …

Current and emerging treatment options for uterine fibroids

M Ali, M Ciebiera, M Wlodarczyk, S Alkhrait, E Maajid… - Drugs, 2023 - Springer
Uterine fibroids are the most common benign neoplasm of the female reproductive tract in
reproductive age women. Their prevalence is age dependent and can be detected in up to …

Contemporary approaches in the management of uterine leiomyomas

S Singh, P Kumar, SS Rathore, Y Singh… - European Journal of …, 2023 - Elsevier
Background Leiomyomas (fibroids), the most common benign solid tumours in females,
originate from the myometrium and are associated with poor quality of life for patients. The …

Efficacy and safety of vilaprisan in women with uterine fibroids: data from the ASTEROID 3 randomized controlled trial

A Al-Hendy, YF Zhou, T Faustmann… - F&S Science, 2023 - Elsevier
Objective Vilaprisan is a highly potent selective progesterone receptor modulator shown to
reduce heavy menstrual bleeding, induce amenorrhea, and diminish uterine fibroid volume …

Systematic review of oral pharmacotherapeutic options for the management of uterine fibroids

RJ Rovelli, NE Cieri-Hutcherson… - Journal of the American …, 2022 - Elsevier
Background Uterine fibroids constitute a significant health problem in the United States,
affecting upward of 11 million people. Objective Characterize the literature regarding the …

Experimental and new investigational drugs for the treatment of uterine fibroids

G Evangelisti, S Ferrero, U Perrone… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Uterine fibroids, the most prevalent benign tumors among reproductive-age
women, pose treatment challenges that range from surgical interventions to medical …

Management of women with abnormal uterine bleeding: Clinical practice guidelines of the French National College of Gynaecologists and Obstetricians (CNGOF)

JL Brun, G Plu-Bureau, C Huchon, X Ah-Kit… - European Journal of …, 2023 - Elsevier
Abstract Objective To provide French guidelines for the management of women with
abnormal uterine bleeding (AUB). Design A consensus committee of 26 experts was formed …

Clinical pharmacokinetics and pharmacodynamics of the selective progesterone receptor modulator vilaprisan: a comprehensive overview

MH Schultze-Mosgau, BA Ploeger, M Frei… - Clinical …, 2022 - Springer
Vilaprisan is a highly potent selective progesterone receptor modulator in development for
the treatment of symptomatic uterine fibroids and endometriosis. Its pharmacokinetics are …

Assessment of the safe and efficacious dose of the selective progesterone receptor modulator vilaprisan for the treatment of patients with uterine fibroids by exposure …

G Sutter, M Frei, MH Schultze‐Mosgau… - British Journal of …, 2022 - Wiley Online Library
Aims We report population pharmacokinetic (popPK) and exposure–response (E–R)
analyses for efficacy (induced amenorrhoea [IA]) and safety (unbound oestradiol [E2] …

Prise en charge des ménorragies: recommandations pour la pratique clinique du Collège national des gynécologues et obstétriciens français (CNGOF)

JL Brun, G Plu-Bureau, C Huchon, X Ah-Kit… - … Obstétrique Fertilité & …, 2022 - Elsevier
Résumé Objectif Émettre des recommandations pour la prise en charge des femmes ayant
des ménorragies. Conception Un comité de 26 experts a été constitué. Une politique de …