Comparing the pharmacokinetic and pharmacodynamic qualities of current and future therapies for uterine fibroids
Introduction Uterine fibroids are the most common benign gynecological tumors affecting
women of reproductive ages. Although surgery is the definitive treatment choice, several …
women of reproductive ages. Although surgery is the definitive treatment choice, several …
Current and emerging treatment options for uterine fibroids
M Ali, M Ciebiera, M Wlodarczyk, S Alkhrait, E Maajid… - Drugs, 2023 - Springer
Uterine fibroids are the most common benign neoplasm of the female reproductive tract in
reproductive age women. Their prevalence is age dependent and can be detected in up to …
reproductive age women. Their prevalence is age dependent and can be detected in up to …
Contemporary approaches in the management of uterine leiomyomas
S Singh, P Kumar, SS Rathore, Y Singh… - European Journal of …, 2023 - Elsevier
Background Leiomyomas (fibroids), the most common benign solid tumours in females,
originate from the myometrium and are associated with poor quality of life for patients. The …
originate from the myometrium and are associated with poor quality of life for patients. The …
Efficacy and safety of vilaprisan in women with uterine fibroids: data from the ASTEROID 3 randomized controlled trial
A Al-Hendy, YF Zhou, T Faustmann… - F&S Science, 2023 - Elsevier
Objective Vilaprisan is a highly potent selective progesterone receptor modulator shown to
reduce heavy menstrual bleeding, induce amenorrhea, and diminish uterine fibroid volume …
reduce heavy menstrual bleeding, induce amenorrhea, and diminish uterine fibroid volume …
Systematic review of oral pharmacotherapeutic options for the management of uterine fibroids
RJ Rovelli, NE Cieri-Hutcherson… - Journal of the American …, 2022 - Elsevier
Background Uterine fibroids constitute a significant health problem in the United States,
affecting upward of 11 million people. Objective Characterize the literature regarding the …
affecting upward of 11 million people. Objective Characterize the literature regarding the …
Experimental and new investigational drugs for the treatment of uterine fibroids
G Evangelisti, S Ferrero, U Perrone… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Uterine fibroids, the most prevalent benign tumors among reproductive-age
women, pose treatment challenges that range from surgical interventions to medical …
women, pose treatment challenges that range from surgical interventions to medical …
Management of women with abnormal uterine bleeding: Clinical practice guidelines of the French National College of Gynaecologists and Obstetricians (CNGOF)
JL Brun, G Plu-Bureau, C Huchon, X Ah-Kit… - European Journal of …, 2023 - Elsevier
Abstract Objective To provide French guidelines for the management of women with
abnormal uterine bleeding (AUB). Design A consensus committee of 26 experts was formed …
abnormal uterine bleeding (AUB). Design A consensus committee of 26 experts was formed …
Clinical pharmacokinetics and pharmacodynamics of the selective progesterone receptor modulator vilaprisan: a comprehensive overview
MH Schultze-Mosgau, BA Ploeger, M Frei… - Clinical …, 2022 - Springer
Vilaprisan is a highly potent selective progesterone receptor modulator in development for
the treatment of symptomatic uterine fibroids and endometriosis. Its pharmacokinetics are …
the treatment of symptomatic uterine fibroids and endometriosis. Its pharmacokinetics are …
Assessment of the safe and efficacious dose of the selective progesterone receptor modulator vilaprisan for the treatment of patients with uterine fibroids by exposure …
G Sutter, M Frei, MH Schultze‐Mosgau… - British Journal of …, 2022 - Wiley Online Library
Aims We report population pharmacokinetic (popPK) and exposure–response (E–R)
analyses for efficacy (induced amenorrhoea [IA]) and safety (unbound oestradiol [E2] …
analyses for efficacy (induced amenorrhoea [IA]) and safety (unbound oestradiol [E2] …
Prise en charge des ménorragies: recommandations pour la pratique clinique du Collège national des gynécologues et obstétriciens français (CNGOF)
JL Brun, G Plu-Bureau, C Huchon, X Ah-Kit… - … Obstétrique Fertilité & …, 2022 - Elsevier
Résumé Objectif Émettre des recommandations pour la prise en charge des femmes ayant
des ménorragies. Conception Un comité de 26 experts a été constitué. Une politique de …
des ménorragies. Conception Un comité de 26 experts a été constitué. Une politique de …