Is early-onset cancer an emerging global epidemic? Current evidence and future implications
T Ugai, N Sasamoto, HY Lee, M Ando… - Nature Reviews …, 2022 - nature.com
Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …
Structural variations in cancer and the 3D genome
F Dubois, N Sidiropoulos, J Weischenfeldt… - Nature Reviews …, 2022 - nature.com
Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …
genetic alteration but difficulties in detecting and interpreting them have limited our …
Accurate and efficient detection of gene fusions from RNA sequencing data
S Uhrig, J Ellermann, T Walther, P Burkhardt… - Genome …, 2021 - genome.cshlp.org
The identification of gene fusions from RNA sequencing data is a routine task in cancer
research and precision oncology. However, despite the availability of many computational …
research and precision oncology. However, despite the availability of many computational …
The DNA methylation landscape of advanced prostate cancer
Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …
methylation landscape of metastatic cancer has never been defined. Through whole …
[HTML][HTML] Integrated omics of metastatic colorectal cancer
We integrate the genomics, proteomics, and phosphoproteomics of 480 clinical tissues from
146 patients in a Chinese colorectal cancer (CRC) cohort, among which 70 had metastatic …
146 patients in a Chinese colorectal cancer (CRC) cohort, among which 70 had metastatic …
High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants
Accurate identification of tumor-derived somatic variants in plasma circulating cell-free DNA
(cfDNA) requires understanding of the various biological compartments contributing to the …
(cfDNA) requires understanding of the various biological compartments contributing to the …
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …
Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression
Single-cell RNA sequencing studies have suggested that total mRNA content correlates with
tumor phenotypes. Technical and analytical challenges, however, have so far impeded at …
tumor phenotypes. Technical and analytical challenges, however, have so far impeded at …
Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
Age-associated differences in the cancer molecular landscape
Cancer is an age-related disease, as incidence and mortality for most types of cancer
increase with age. However, how molecular alterations in tumors differ among patients of …
increase with age. However, how molecular alterations in tumors differ among patients of …