Introduction: Drug release and oral absorption of drugs with pH-dependent solubility are
influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption …

Published reports have clearly shown that weakly basic drugs which have low solubility at
high pH could have impaired absorption in patients with high gastric pH thus leading to …

Drug delivery systems (DDS) control the amount, rate, and site of administration of drug
substances in the body as well as their release and ADME (absorption, distribution …

Many drug candidates are poorly water-soluble. Microenvironmental pH (pHM) modification
in buccal/sublingual dosage forms has attracted increasing interest as a promising …

Abstract Formulation development of poorly water-soluble compounds can be challenging
because of incomplete dissolution that causes low and variable bioavailability. Enhancing …

It is our hypothesis that the presence of an absorptive sink for in-vitro dissolution
experiments is decisive to predict extent and duration of super-saturation of low soluble …

Advances in understanding of human disease have prompted the US Food and Drug
Administration to classify certain molecules as “break-through therapies,” providing an …

This study assessed the in vitro–in vivo correlation in cocrystal dissolution based on the
coformer behavior. 4-Aminobenzoic acid (4ABA) was used as a coformer. Cocrystals of …

The aim of the present work was to design a pH-modified solid dispersion (pH M-SD) that
can improve the dissolution and bioavailability of poorly water-soluble weakly basic …

The purpose of this study was to improve the aqueous solubility and oral bioavailability of
practically water-insoluble carvedilol using pH-modulating drug delivery systems. Since …