Subpopulations of cells that escape anti-cancer treatment can cause relapse in cancer
patients. Therefore, measurements of cellular-level tumor heterogeneity could enable …

The classical examination of histology slides from a mouse model of breast cancer has been
extended in this study to incorporate modern multiphoton excitation and photon-counting …

Solar ultraviolet longwave UVA1 exposure of human skin has short-term consequences at
cellular and molecular level, leading at long-term to photoaging. Following exposure …

Minimally invasive, specific measurement of cellular energy metabolism is crucial for
understanding cerebral pathophysiology. Here, we present high-resolution, in vivo …

Autofluorescence imaging (AFI) has greatly accelerated in the last decade, way past its
origins in detecting endogenous signals in biological tissues to identify differences between …

GSK3β is a serine threonine kinase implicated in the progression of Alzheimer's disease.
Although the role of GSK3β in growth and pathology has been extensively studied, little is …

Optical metabolic imaging measures fluorescence intensity and lifetimes from metabolic
cofactors nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) …

Heterogeneous populations within a tumor have varying metabolic profiles, which can
muddle the interpretation of bulk tumor imaging studies of treatment response. Although …

Purpose To determine alterations in the retina of patients with Alzheimer's disease (AD) by
the newly developed technique of fluorescence lifetime imaging ophthalmoscopy (FLIO) in a …

Extracellular matrix (ECM) mechanical properties upregulate cancer invasion, cell
contractility, and focal adhesion formation. Alteration in energy metabolism is a known …