Molecular mechanisms of transgenerational epigenetic inheritance

MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

[PDF][PDF] Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care

NJ Pillon, RJF Loos, SM Marshall, JR Zierath - Cell, 2021 - cell.com
The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is
expected to rise further, secondary to the growing aging, sedentary population. The strain on …

Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice

Y Takahashi, MM Valencia, Y Yu, Y Ouchi, K Takahashi… - Cell, 2023 - cell.com
Transgenerational epigenetic inheritance in mammals remains a debated subject. Here, we
demonstrate that DNA methylation of promoter-associated CpG islands (CGIs) can be …

How does epigenetics influence the course of evolution?

A Ashe, V Colot, BP Oldroyd - … transactions of the …, 2021 - royalsocietypublishing.org
Epigenetics is the study of changes in gene activity that can be transmitted through cell
divisions but cannot be explained by changes in the DNA sequence. Epigenetic …

An integrative framework for understanding the mechanisms and multigenerational consequences of transgenerational plasticity

AM Bell, JK Hellmann - Annual Review of Ecology, Evolution …, 2019 - annualreviews.org
Transgenerational plasticity (TGP) occurs when the environment experienced by a parent
influences the development of their offspring. In this article, we develop a framework for …

Biological pathways for historical trauma to affect health: A conceptual model focusing on epigenetic modifications

AKS Conching, Z Thayer - Social Science & Medicine, 2019 - Elsevier
Despite their unique histories, environments, and lifestyles, historically subjugated
populations consistently show poorer health outcomes compared to the general population …

Limitations of cross‐and multigenerational plasticity for marine invertebrates faced with global climate change

M Byrne, SA Foo, PM Ross… - Global Change …, 2020 - Wiley Online Library
Although cross generation (CGP) and multigenerational (MGP) plasticity have been
identified as mechanisms of acclimation to global change, the weight of evidence indicates …

Soma-to-germline RNA communication

CC Conine, OJ Rando - Nature Reviews Genetics, 2022 - nature.com
More than a century ago, August Weissman defined a distinction between the germline
(responsible for propagating heritable information from generation to generation) and the …

[HTML][HTML] Paternal contributions to offspring health: role of sperm small RNAs in intergenerational transmission of epigenetic information

U Sharma - Frontiers in cell and developmental biology, 2019 - frontiersin.org
The most fundamental process for the perpetuation of a species is the transfer of information
from parent to offspring. Although genomic DNA contributes to the majority of the …

Real‐time genomics for One Health

L Urban, A Perlas, O Francino… - Molecular Systems …, 2023 - embopress.org
The ongoing degradation of natural systems and other environmental changes has put our
society at a crossroad with respect to our future relationship with our planet. While the …