Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct
pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; …

High affinity antibodies result from interactions between B cells and T follicular helper (Tfh)
cells in germinal centers (GCs). Recent studies have identified an effector subset of T …

Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality
after allogeneic hematopoietic stem cell transplantation. Having shown that germinal center …

CD4+ T cells are central to various immune responses, but the molecular programs that
drive and maintain CD4+ T cell immunity are not entirely clear. Here we identify a stem-like …

De novo donor-specific HLA antibodies (dnDSA) are recognized as a risk factor for
premature allograft failure. Determinants of DSA specificity are generated via the indirect …

De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-
mediated rejection (AMR) and causes late graft loss. Previously, we demonstrated that …

The identification of T‐helper 9 (Th9), Th17, Th22 cells as distinct subsets of CD 4+ T cells
has extended the Th1/Th2 paradigm in the adaptive immunity. In the past decade, many …

The generation of antibodies against donor-specific major histocompatibility complex (MHC)
antigens, a type of donor-specific antibodies (DSAs), after transplantation requires that …

With the advent of cellular therapies, it has become clear that the success of future therapies
in prolonging allograft survival will require an intimate understanding of the allorecognition …