[HTML][HTML] Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?

CB Mishra, M Tiwari, CT Supuran - Medicinal Research …, 2020 - Wiley Online Library
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are widely distributed metalloenzymes in
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …

[HTML][HTML] European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea

W Randerath, J Verbraecken… - European …, 2021 - Eur Respiratory Soc
Treatment of obstructive sleep apnoea (OSA) in adults is evolving, as new therapies have
been explored and introduced in clinical practice, while other approaches have been refined …

On the rise and fall of the apnea− hypopnea index: A historical review and critical appraisal

DA Pevernagie, B Gnidovec‐Strazisar… - Journal of sleep …, 2020 - Wiley Online Library
Summary The publication of “The Sleep Apnea Syndromes” by Guilleminault et al. in the
1970s hallmarked the discovery of a new disease entity involving serious health …

Obstructive sleep apnea: current perspectives

AM Osman, SG Carter, JC Carberry… - Nature and science of …, 2018 - Taylor & Francis
The prevalence of obstructive sleep apnea (OSA) continues to rise. So too do the health,
safety, and economic consequences. On an individual level, the causes and consequences …

Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review

MR Cowie, D Linz, S Redline, VK Somers… - Journal of the American …, 2021 - jacc.org
Sleep disordered breathing causes repetitive episodes of nocturnal hypoxemia, sympathetic
nervous activation, and cortical arousal, often associated with excessive daytime sleepiness …

Sleep apnea and cardiovascular disease: lessons from recent trials and need for team science

LF Drager, RD McEvoy, F Barbe, G Lorenzi-Filho… - Circulation, 2017 - Am Heart Assoc
Emerging research highlights the complex interrelationships between sleep-disordered
breathing and cardiovascular disease, presenting clinical and research opportunities as well …

Global burden of sleep‐disordered breathing and its implications

MM Lyons, NY Bhatt, AI Pack, UJ Magalang - Respirology, 2020 - Wiley Online Library
One‐seventh of the world's adult population, or approximately one billion people, are
estimated to have OSA. Over the past four decades, obesity, the main risk factor for OSA, has …

Evaluation and management of adults with obstructive sleep apnea syndrome

JJ Lee, KM Sundar - Lung, 2021 - Springer
Obstructive sleep apnea syndrome (OSAS) is a common and underdiagnosed medical
condition characterized by recurrent sleep-dependent pauses and reductions in airflow …

Phenotypic approaches to obstructive sleep apnoea–new pathways for targeted therapy

DJ Eckert - Sleep medicine reviews, 2018 - Elsevier
People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …