With the widespread use of antibiotic drugs worldwide and the global increase in the
number of immunodeficient patients, fungal infections have become a serious threat to …

Highlights•There is a dire need for novel antifungal therapies.•Recent clinical trials of directly
repurposed drugs have failed.•The most recently approved antifungals underwent …

Drug-induced nephrotoxicity is still a significant obstacle in pharmacotherapy of various
diseases and it accounts for around 25% of serious side-effects reported after drug …

Fungal infections cause severe and life-threatening complications especially in
immunocompromised individuals. Antifungals targeting cellular machinery and cell …

Dual-target (CYP51/PD-L1) plays an important role in the process of fungal proliferation and
immune suppression. A series of novel quinazoline compounds with dual-target inhibition …

While majority of the current treatment approaches for cancer remain expensive and are
associated with several side effects, development of new treatment modalities takes a …

In this study, PD-L1 and CYP51 were selected as key dual-target enzymes, which play an
important role in the process of fungal proliferation and immune suppression. A series of …

Fungal infections are a serious problem affecting many people worldwide, creating critical
economic and medical consequences. Fungi are ubiquitous and can cause invasive …

The incidence of intra-abdominal candidiasis (IAC), characterized by high morbidity and
mortality, has become a serious concern. The limitations of current antifungal drugs on the …

Systemic infection with Cryptococcus neoformans, a dangerous and contagious pathogen
found throughout the world, frequently results in lethal cryptococcal pneumonia and …