Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …

This review summarizes the latest advances that have been made to elucidate the
somatostatinergic system in respect to somatostatin receptor evolution, the development of …

Kisspeptin and G protein-coupled receptor 54 (GPR54) are now acknowledged to play
essential roles in the neural regulation of fertility. Using a transgenic Gpr54 LacZ knock-in …

Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene, first described in 2004 have
now emerged as the most important genetic finding in both autosomal dominant and …

Somatostatin is abundantly expressed in mammalian brain. The peptide binds with high
affinity to six somatostatin receptors, sst1, sst2A and B, sst3 to 5, all belonging to the G …

We have examined the pattern of striatal messenger RNA expression of over 8000 genes in
a rat model of levodopa (l-DOPA)-induced dyskinesia and Parkinson disease (PD). 6 …

We have shown that somatostatin released from activated capsaicin-sensitive nociceptive
nerve endings during inflammatory processes elicits systemic anti-inflammatory and …

Somatostatin is highly expressed in mammalian brain and is involved in many brain
functions such as motor activity, sleep, sensory, and cognitive processes. Five somatostatin …

Growth is a polygenic trait that is under the influence of multiple physiological pathways
regulating energy metabolism and muscle growth. Among the possible growth-regulating …

In mammalian brain, the somatostatin (SRIF: somatotropin release-inhibiting factor) family is
composed of two peptides: SRIF and cortistatin (CST), which interact with five different …