Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases
This article provides an overview of compounds based on imidazo [1, 2-a] pyridine, imidazo
[1, 5-a] pyridine, imidazo [4, 5-b] pyridine and imidazo [4, 5-c] pyridine scaffolds, which act as …
[1, 5-a] pyridine, imidazo [4, 5-b] pyridine and imidazo [4, 5-c] pyridine scaffolds, which act as …
Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl] …
E Pinard, A Alanine, D Alberati, M Bender… - Journal of medicinal …, 2010 - ACS Publications
The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia.
Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine …
Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine …
Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical …
BH Harvey, M Shahid - Pharmacology Biochemistry and Behavior, 2012 - Elsevier
Anxiety disorders are amongst the most common and disabling of psychiatric illnesses and
have severe health and socio-economic implications. Despite the availability of a number of …
have severe health and socio-economic implications. Despite the availability of a number of …
Glycine transport inhibitors in the treatment of schizophrenia
DC Javitt - Novel antischizophrenia treatments, 2012 - Springer
Schizophrenia is a severe neuropsychiatric disorder without adequate current treatment.
Recent theories of schizophrenia focus on disturbances of glutamatergic neurotransmission …
Recent theories of schizophrenia focus on disturbances of glutamatergic neurotransmission …
[HTML][HTML] Bioinformatics and genomic analyses of the suitability of eight riboswitches for antibacterial drug targets
N Pavlova, R Penchovsky - Antibiotics, 2022 - mdpi.com
Antibiotic resistance (AR) is an acute problem that results in prolonged and debilitating
illnesses. AR mortality worldwide is growing and causes a pressing need to research novel …
illnesses. AR mortality worldwide is growing and causes a pressing need to research novel …
Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
U Lange, W Amberg, M Ochse, B Behl, F Pohlki… - US Patent …, 2015 - Google Patents
2004/0026364 A1 2/2004 Kihara WO WO 2004/096761 11, 2004 2005, 0124627 A1 6, 2005
Schadt et al. WO WO 2004/110149 12, 2004 2005/0153963 A1 7/2005 Dargazanli et al. WO …
Schadt et al. WO WO 2004/110149 12, 2004 2005/0153963 A1 7/2005 Dargazanli et al. WO …
Glycine transporters and synaptic function
Glycine is an inhibitory neurotransmitter that is mainly active in the caudal areas of the CNS.
However, glycine also participates in excitatory neurotransmission since it is a co‐agonist of …
However, glycine also participates in excitatory neurotransmission since it is a co‐agonist of …
Glycine transport inhibitors and the treatment of schizophrenia
DC Javitt - Biological psychiatry, 2008 - biologicalpsychiatryjournal.com
The potential role of N-methyl-D-aspartate (NMDA)-type glutamate receptors in the
pathogenesis of schizophrenia was first proposed almost 20 years ago on the basis of …
pathogenesis of schizophrenia was first proposed almost 20 years ago on the basis of …
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors
T Sparey, P Abeywickrema, S Almond… - Bioorganic & medicinal …, 2008 - Elsevier
The 'NMDA hypofunction hypothesis of schizophrenia'can be tested in a number of ways.
DAO is the enzyme primarily responsible for the metabolism of d-serine, a co-agonist for the …
DAO is the enzyme primarily responsible for the metabolism of d-serine, a co-agonist for the …